Paccaud J P, Steiger G, Schifferli J A
Clinique Médicale, Hôpital Cantonal Universitaire, Genève, Suisse.
Complement Inflamm. 1989;6(6):470-9. doi: 10.1159/000463116.
The adherence of complement-reacted immune complexes (ICs) to cells bearing C3b receptors depends on the characteristics of the IC used. The immune adherence of preformed ICs exposed in vitro or in vivo to complement has been well established, and was confirmed using different types of ICs-antigens used: BSA; BSA dimers and trimers; tetanus toxoid, and hepatitis B surface antigen. In contrast the same ICs did not bind to human red blood cells when formed in the presence of serum in vitro. ICs remained negative for immune adherence as well, when formed directly in vivo by the sequential injection of antibody and antigen in guinea pigs. These results suggest that in many circumstances, the elimination of ICs formed in the circulation does not involve immune adherence reactions, possibly because complement in itself inhibits the formation of the large ICs that would bind to C3b receptor-bearing cells.
补体反应免疫复合物（ICs）与带有C3b受体的细胞的黏附取决于所用ICs的特性。体外或体内暴露于补体的预先形成的ICs的免疫黏附已得到充分证实，并使用了不同类型的ICs-抗原进行了验证：牛血清白蛋白（BSA）；BSA二聚体和三聚体；破伤风类毒素和乙型肝炎表面抗原。相比之下，当在体外血清存在下形成时，相同的ICs不与人红细胞结合。当通过在豚鼠中依次注射抗体和抗原直接在体内形成时，ICs的免疫黏附也呈阴性。这些结果表明，在许多情况下，循环中形成的ICs的清除不涉及免疫黏附反应，这可能是因为补体本身抑制了会与带有C3b受体的细胞结合的大ICs的形成。
