Varga L, Thiry E, Füst G
National Institute of Haematology and Blood Transfusion, Budapest, Hungary.
Immunology. 1988 Jul;64(3):381-4.
The binding of 125I-BSA-anti-BSA immune complexes (IC) formed in the presence of complement (nascent IC) and those that reacted with complement after their formation (preformed IC) to human erythrocytes was studied. The effect of antigen-antibody ratios and serum dilutions on IC binding to red blood cells (RBC) were also investigated. A dramatic difference was found between the behaviour of the two types of complexes: while preformed IC bound effectively to human RBC after their interaction with complement, no efficient RBC-binding was observed with nascent BSA-anti-BSA complexes formed in the presence of complement. Changing the antigen-antibody ratio or dilution of serum did not affect markedly the extent of difference between the binding of preformed and nascent IC. Our findings do not support the essential role of red blood cells in the elimination of each type of IC.
研究了在补体存在下形成的125I-BSA-抗BSA免疫复合物（IC）（新生IC）以及形成后与补体反应的那些复合物（预先形成的IC）与人红细胞的结合情况。还研究了抗原抗体比例和血清稀释度对IC与红细胞（RBC）结合的影响。发现这两种类型的复合物的行为存在显著差异：虽然预先形成的IC在与补体相互作用后能有效地与人RBC结合，但在补体存在下形成的新生BSA-抗BSA复合物未观察到有效的RBC结合。改变抗原抗体比例或血清稀释度并未明显影响预先形成的IC和新生IC结合之间的差异程度。我们的研究结果不支持红细胞在清除每种类型IC中的关键作用。
