Shono M, Hayashi K, Sugimoto R
Division of Dermatology, Saiseikai Kawaguchi General Hospital, Saitama, Japan.
Contact Dermatitis. 1989 Oct;21(4):225-7. doi: 10.1111/j.1600-0536.1989.tb03200.x.
We report 6 cases of contact sensitivity to croconazole hydrochloride, a new imidazole antimycotic drug introduced to the Japanese market in 1986, and available as 1% gel and cream. 6 sensitized patients reacted on patch testing to croconazole hydrochloride down to 0.5 to 0.1% pet, and 3 appeared to be cross-sensitized to sulconazole nitrate. In Japan, allergic contact dermatitis to this drug has now been detected in 12 cases, including our own 6. Prescribers should be aware of contact sensitivity to this drug.
我们报告了6例对盐酸氯康唑接触过敏的病例。盐酸氯康唑是1986年引入日本市场的一种新型咪唑类抗真菌药物，有1%的凝胶和乳膏剂型。6例过敏患者在斑贴试验中对低至0.5%至0.1%的盐酸氯康唑凡士林制剂有反应，3例似乎对硝酸硫康唑交叉过敏。在日本，包括我们报告的6例在内，现已检测到12例对该药物的过敏性接触性皮炎。开处方者应注意该药物的接触过敏情况。
