Santucci B, Ferrari P V, Cristaudo A, Cannistraci C, Picardo M
Servizio di Allergologia, Istituto Dermosifilopatico di S. Maria e San Gallicano, Roma, Italy.
Contact Dermatitis. 1989 Oct;21(4):245-8. doi: 10.1111/j.1600-0536.1989.tb03203.x.
In 1988, 64% of our patients patch test positive to at least 1 allergen of the ICDRG standard series were nickel sensitive. In 70% of 300 patients evaluated, dermatitis started on the earlobes and was related to the regular wearing of cheap earrings. At the same time, 62% of 735 young schoolgirls were found to have dermatitis of their earlobes and all regularly wore cheap earrings. 9 clasps and clips commonly used in earrings released high quantities of nickel ions (between 49 and 103 micrograms/12 h), having been stored in synthetic sweat. A round piece cut from a clasp was taped to the skin of 30 nickel-sensitive patients, previously tested with 20 microliters of NiSO4 5%, 2.5%, 1% aq. solutions, giving a response similar to that caused by the 5% solution. High daily absorption of Ni ions through the skin follows its repetitive exposure to cheap earrings, causing, firstly, a direct inflammatory reaction, then followed, in our opinion, by sensitization.
1988年，在我们的患者中，对国际接触性皮炎研究组（ICDRG）标准系列中至少1种变应原斑贴试验呈阳性的患者中有64%对镍敏感。在接受评估的300例患者中，70%的患者皮炎始于耳垂，且与经常佩戴廉价耳环有关。与此同时，在735名年轻女学生中，62%的人被发现耳垂患有皮炎，她们都经常佩戴廉价耳环。9种常用于耳环的扣环和夹子在合成汗液中储存后会释放大量镍离子（49至103微克/12小时）。从一个扣环上切下的圆形薄片被贴在30名对镍敏感患者的皮肤上，这些患者之前已用20微升5%、2.5%、1%的硫酸镍水溶液进行过测试，其反应与5%溶液引起的反应相似。皮肤反复接触廉价耳环会导致镍离子每日大量经皮吸收，首先引起直接炎症反应，然后在我们看来会引发致敏。
