Gupta Mrinal, Mahajan Vikram K, Mehta Karaninder S, Chauhan Pushpinder S, Rawat Ritu
Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra, Tanda, 176001, Himachal Pradesh, India.
Arch Dermatol Res. 2015 Nov;307(9):767-80. doi: 10.1007/s00403-015-1571-1. Epub 2015 May 19.
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors and comprise three different isoforms namely PPARα, PPARγ, and PPARβ/δ with PPARβ/δ being the predominant subtype in human keratinocytes. After binding with specific ligands, PPARs regulate gene expression, cell growth and differentiation, apoptosis, inflammatory responses, and tumorogenesis. PPARs also modulate a wide variety of skin functions including keratinocyte proliferation, epidermal barrier formation, wound healing, melanocyte proliferation, and sebum production. Recent studies have shown the importance of PPARs in the pathogenesis of many dermatological disorders. Clinical trials have suggested possible role of PPAR agonists in the management of various dermatoses ranging from acne vulgaris, psoriasis, hirsutism, and lipodystrophy to cutaneous malignancies including melanoma. This article is intended to be a primer for dermatologists in their understanding of clinical relevance of PPARs and PPAR agonists in dermatology therapeutics.
过氧化物酶体增殖物激活受体（PPARs）是核激素受体，包括三种不同的亚型，即PPARα、PPARγ和PPARβ/δ，其中PPARβ/δ是人类角质形成细胞中的主要亚型。与特定配体结合后，PPARs调节基因表达、细胞生长和分化、细胞凋亡、炎症反应及肿瘤发生。PPARs还调节多种皮肤功能，包括角质形成细胞增殖、表皮屏障形成、伤口愈合、黑素细胞增殖和皮脂分泌。最近的研究表明PPARs在许多皮肤病的发病机制中具有重要作用。临床试验提示PPAR激动剂在治疗各种皮肤病中可能发挥作用，这些皮肤病范围从寻常痤疮、银屑病、多毛症和脂肪营养不良到包括黑色素瘤在内的皮肤恶性肿瘤。本文旨在为皮肤科医生提供一个入门指南，帮助他们理解PPARs和PPAR激动剂在皮肤病治疗中的临床相关性。
