Li Jia-Rui, Sun Yu, Liu Lin
Invasive Technology Department, The First Hospital of Jilin University, Changchun, China E-mail :
Asian Pac J Cancer Prev. 2015;16(9):4003-6. doi: 10.7314/apjcp.2015.16.9.4003.
Objecive: To investigate the clinical safety and efficacy of CT-guided 125iodine (125I) seed implantation combined with percutaneous intra-tumor injection of chemotherapy emulsion of lobaplatin and lipiodol in treating patients with advanced lung cancer.
Patients with advanced lung cancer and treated with spiral CT-guided 125I seed implantation combined with percutaneous intra-tumor injection of chemotherapy emulsion of lobaplatin and lipiodol were recruited.
Of the 36 patients, there were 40 nidi in total. The contrast-enhanced CT evaluation was conducted 60 d after treatment. Response evaluation suggested that 4 patients achieved complete remission (CR), 24 partial remission (PR), 4 stable disease (SD) and 4 progression disease (PD), with a total response rate of 77.8% (28/36).
CT-guided 125I seed implantation combined with percutaneous intra-tumor injection of chemotherapy emulsion of lobaplatin and lipiodol are safe and effective in treating patients with advanced lung cancer.
目的：探讨CT引导下125碘（125I）粒子植入联合经皮瘤内注射洛铂与碘油化疗乳剂治疗晚期肺癌患者的临床安全性和疗效。
招募接受螺旋CT引导下125I粒子植入联合经皮瘤内注射洛铂与碘油化疗乳剂治疗的晚期肺癌患者。
36例患者共40个病灶。治疗后60天进行CT增强评估。疗效评估显示，4例患者完全缓解（CR），24例部分缓解（PR），4例疾病稳定（SD），4例疾病进展（PD），总有效率为77.8%（28/36）。
CT引导下125I粒子植入联合经皮瘤内注射洛铂与碘油化疗乳剂治疗晚期肺癌患者安全有效。
