Wu B M, Liu J K, Wang Z L
Zhonghua Nei Ke Za Zhi. 1989 Aug;28(8):450-3, 507.
A comparative study of EEG between neurological and myxedematous cretins was carried out in a total of 61 cases. The results were as follows: (1) The changes of EEG in myxedematous cretins appeared to be more obvious than those in neurological cretins; (2) The degree of mental retardation in cretins was not parallel to the degree of the abnormality of EEG; (3) with thyroid therapy, EEG in cretins was improved. The improvement rate in myxedematous cretins was higher than that in neurological cretins; (4) Brain CT scan was carried out in 50 cases of those cretins. It was found that the abnormality of certain intracerebral structure in myxedematous cretins appeared to be more obvious than that in neurological cretins. The change of EEG appeared in the same way as well. This is in contradiction to the traditional knowledge that the defect of neurological system in neurological cretinism was more severe than that in myxedematous cretinism. The current classification of cretins into neurological and myxedematous cretins does not reflect the changes of pathophysiology properly.
对总共61例神经型克汀病患者和黏液水肿型克汀病患者进行了脑电图的对比研究。结果如下:(1)黏液水肿型克汀病患者脑电图的变化似乎比神经型克汀病患者更明显;(2)克汀病患者的智力迟钝程度与脑电图异常程度不平行;(3)经过甲状腺治疗,克汀病患者的脑电图有所改善。黏液水肿型克汀病患者的改善率高于神经型克汀病患者;(4)对其中50例克汀病患者进行了脑部CT扫描。发现黏液水肿型克汀病患者某些脑内结构的异常似乎比神经型克汀病患者更明显。脑电图的变化也以同样的方式出现。这与传统认知相矛盾,传统认知认为神经型克汀病的神经系统缺陷比黏液水肿型克汀病更严重。目前将克汀病分为神经型和黏液水肿型并不能恰当地反映病理生理学的变化。