Fang G X
Zhonghua Nei Ke Za Zhi. 1989 Aug;28(8):486-9, 511.
The clinical features and long-term outcome of 91 cases of adult-onset PSGN in Hong Kong were reported. There were 46 male and 45 female with age ranging from 13 to 56 yrs (mean 18.6). The diagnosis was based on clinical manifestations and renal biopsy was performed in 29 cases. The main manifestations were acute nephritic syndrome (72.5%) and acute nephritic-nephrotic syndrome (27.5%). Serum creatinine was increased in 48.4% of the patients at presentation. Four cases presented with acute renal failure. Serial serum C3 levels were determined in 48 patients. It was decreased in all patients at presentation but returned to normal within 15 weeks. The follow-up duration of this series ranged from I to 19 yrs (mean 4.73 yr) 67.03% recovered early (within 3 mts); 14.29% recovered later (from 6 mts to 7 yrs): 16.48% had persistent or intermittent proteinuria and or haematuria. Two cases developed chronic renal insufficiency. Our results suggested that the prognosis of PSGN in adults is relatively good and the indications for renal biopsy in adult-onset PSGN were discussed.
报道了香港91例成人起病的急性感染后肾小球肾炎（PSGN）的临床特征及长期预后。其中男性46例，女性45例，年龄13至56岁（平均18.6岁）。诊断基于临床表现，29例行肾活检。主要表现为急性肾炎综合征（72.5%）和急性肾炎-肾病综合征（27.5%）。就诊时48.4%的患者血清肌酐升高。4例出现急性肾衰竭。48例患者测定了系列血清C3水平。所有患者就诊时C3均降低，但在15周内恢复正常。该系列随访时间为1至19年（平均4.73年），67.03%早期恢复（3个月内）；14.29%较晚恢复（6个月至7年）；16.48%有持续性或间歇性蛋白尿和/或血尿。2例发展为慢性肾功能不全。我们的结果提示成人PSGN预后相对良好，并对成人起病PSGN肾活检的指征进行了讨论。
