难治性结节性支气管扩张型鸟分枝杆菌复合群肺病从间歇治疗转换为每日治疗的反应
Response to Switch from Intermittent Therapy to Daily Therapy for Refractory Nodular Bronchiectatic Mycobacterium avium Complex Lung Disease.
作者信息
Koh Won-Jung, Jeong Byeong-Ho, Jeon Kyeongman, Park Hye Yun, Kim Su-Young, Huh Hee Jae, Ki Chang-Seok, Lee Nam Yong, Shin Sung Jae, Daley Charles L
机构信息
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
出版信息
Antimicrob Agents Chemother. 2015 Aug;59(8):4994-6. doi: 10.1128/AAC.00648-15. Epub 2015 May 18.
Abstract
Intermittent three-times-weekly antibiotic therapy is recommended for the initial treatment of patients with noncavitary nodular bronchiectatic Mycobacterium avium complex lung disease. Although some experts recommend switching from intermittent to daily therapy for patients whose sputum has persistent positive cultures after intermittent therapy, the clinical efficacy of these modifications is unknown. Of 20 patients whose sputum had persistent positive cultures after 12 months of intermittent antibiotic therapy, specimens from 6 patients (30%) achieved a negative culture after a change to daily therapy.
摘要
对于非空洞性结节性支气管扩张鸟分枝杆菌复合群肺病患者的初始治疗，建议采用每周三次的间歇性抗生素治疗。尽管一些专家建议，对于间歇性治疗后痰培养持续阳性的患者，应从间歇性治疗改为每日治疗，但这些调整的临床疗效尚不清楚。在20例接受12个月间歇性抗生素治疗后痰培养持续阳性的患者中，6例患者（30%）的标本在改为每日治疗后培养结果转为阴性。
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