Christman Mitalee P, Turbett Sarah E, Sengupta Soma, Bakhadirov Khamidulla U, Williamson Craig A, Nayak Lakshmi, Milligan Tracey, Katz Joel T
Harvard Medical School , Boston, MA , USA.
Division of Infectious Diseases , Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA.
Oxf Med Case Reports. 2014 Mar 12;2014(1):1-4. doi: 10.1093/omcr/omu001. eCollection 2014 Apr.
Although herpes simplex encephalitis is not classically considered an opportunistic infection, reactivation of herpes simplex is being seen increasingly in patients with cancer or immunosuppression. The authors present a patient with malignant glioma and HSV-1 encephalitis whose PCR-proven encephalitis recurred after temozolomide (TMZ) chemoradiation despite acyclovir therapy, and summarize details of four other cases of HSV-1 encephalitis associated with TMZ. The similarity among these cases raises the likely need for longer treatment courses and/or oral suppressive therapy in patients at risk for herpes simplex infections who are receiving TMZ.
虽然单纯疱疹性脑炎通常不被视为机会性感染，但在癌症患者或免疫抑制患者中，单纯疱疹病毒的再激活越来越常见。作者报告了一名患有恶性胶质瘤和HSV-1脑炎的患者，尽管接受了阿昔洛韦治疗，但在替莫唑胺（TMZ）放化疗后，经PCR证实的脑炎仍复发，并总结了其他4例与TMZ相关的HSV-1脑炎病例的细节。这些病例之间的相似性表明，对于接受TMZ治疗且有单纯疱疹病毒感染风险的患者，可能需要更长疗程的治疗和/或口服抑制疗法。
