大鼠中亚硫酸钠致畸潜力的评估。

Evaluation of teratogenic potential of sodium sulfite in rats.

作者信息

Itami T, Ema M, Kawasaki H, Kanoh S

机构信息

National Institute of Hygienic Sciences, Osaka Branch, Japan.

出版信息

Drug Chem Toxicol. 1989 Jun;12(2):123-35. doi: 10.3109/01480548908999149.

DOI:10.3109/01480548908999149

PMID:2598829

Abstract

The teratogenicity of sodium sulfite was examined in Wistar rats. The pregnant rats were fed diets containing 5, 2.5, 1.25, 0.63 or 0.32% of sodium sulfite heptahydrate(Na2SO3.7H2O) ad libitum from day 8 to 20 of pregnancy. Maternal toxicity, as evidenced by decreased body weight gain and decreased food consumption was observed at the 5% group, but no clinical signs of toxicity were observed. A significant reduction in the fetal body weight of both sexes was observed in all dose groups except 2.5% group. No significant differences in the numbers of live fetuses and intrauterine death (dead fetuses and resorptions) or sex ratios of fetuses were found between the sodium sulfite-treated and control groups. Fetal external, skeletal and internal malformations were not observed at any dose level. However, several types of skeletal and internal variations as well as delayed ossifications were observed in some groups treated with sodium sulfite, but the incidences were not significantly different from controls. Also, some fetuses with dilatation of the renal pelvis and the lateral ventricle were found in all groups except 1.25% group, but there was no dose-response. The live birth index and survival rate of offspring within 4 weeks and their body weight gain at 3 weeks after birth were not affected by sodium sulfite-treatment. In conclusion, sodium sulfite (0, 0.32, 0.63, 1.25, 2.5 or 5.0% as Na2SO3.7H2O) administered in the diet to Wistar rats during days 8-20 of pregnancy produced related signs of fetal toxicity but no evidence of teratogenicity.

摘要

在Wistar大鼠中检测了亚硫酸钠的致畸性。从妊娠第8天至20天，给怀孕大鼠随意喂食含5%、2.5%、1.25%、0.63%或0.32%七水合亚硫酸钠（Na2SO3·7H2O）的饲料。在5%组观察到母体毒性，表现为体重增加减少和食物消耗减少，但未观察到毒性的临床症状。除2.5%组外，所有剂量组均观察到两性胎儿体重显著降低。亚硫酸钠处理组与对照组之间在活胎数量、宫内死亡（死胎和吸收胎）数量或胎儿性别比例方面未发现显著差异。在任何剂量水平下均未观察到胎儿的外部、骨骼和内部畸形。然而，在一些用亚硫酸钠处理的组中观察到了几种类型的骨骼和内部变异以及骨化延迟，但发生率与对照组无显著差异。此外，除1.25%组外，所有组均发现一些胎儿有肾盂和侧脑室扩张，但无剂量反应关系。亚硫酸钠处理对活产指数、4周内后代存活率及其出生后3周的体重增加没有影响。总之，在妊娠第8 - 20天给Wistar大鼠喂食含0、0.32%、0.63%、1.25%、2.5%或5.0%（以Na2SO3·7H2O计）亚硫酸钠的饲料会产生相关的胎儿毒性迹象，但没有致畸性证据。