Itami T, Ema M, Kawasaki H
National Institute of Hygienic Sciences, Osaka, Japan.
Drug Chem Toxicol. 1993;16(4):369-82. doi: 10.3109/01480549308998227.
The teratogenicity of p-tert-butylphenol formaldehyde resin, novolak type, (PTBP-FR) was examined in Wistar rats. Pregnant rats were fed diets containing 0, 2.5, 5 or 10% of PTBP-FR ad libitum from day 6 to day 15 of pregnancy. Maternal toxicity, as evidenced by a decreased maternal body weight gain and food consumption, was observed in the 5 and 10% dose groups. However, treatment-related clinical signs were not observed. No significant reductions in the fetal body or placental weights were observed in any dose group. There were no significant differences in the number of live fetuses, intrauterine deaths (dead fetuses and resorptions), or fetal sex ratios found between the PTBP-FR-treated and control groups. Although external and internal malformations including short tail, dilatation of the cerebral ventricle and the renal pelvis and dextrocardia, and some skeletal variations were observed in fetuses at some groups treated with PTBP-FR, the incidences of these morphological alterations were not statistically different from controls. In conclusion, PTBP-FR administered orally to Wistar rats during days 6-15 of gestation produced no related signs of developmental toxicity.
研究了线型对叔丁基苯酚甲醛树脂（PTBP - FR）对Wistar大鼠的致畸性。在妊娠第6天至第15天，给怀孕大鼠随意喂食含0%、2.5%、5%或10% PTBP - FR的日粮。在5%和10%剂量组中观察到母体毒性，表现为母体体重增加和食物摄入量减少。然而，未观察到与治疗相关的临床症状。在任何剂量组中，均未观察到胎儿体重或胎盘重量有显著降低。PTBP - FR处理组与对照组之间，活胎数量、宫内死亡（死胎和吸收胎）或胎儿性别比例均无显著差异。尽管在一些用PTBP - FR处理的组中，胎儿出现了包括短尾、脑室和肾盂扩张、右位心等外部和内部畸形以及一些骨骼变异，但这些形态学改变的发生率与对照组相比无统计学差异。总之，在妊娠第6 - 15天对Wistar大鼠口服PTBP - FR未产生相关的发育毒性迹象。
