原生动物的氧气感知：它们如何呼吸
Oxygen sensing by protozoans: how they catch their breath.
作者信息
West Christopher M, Blader Ira J
机构信息
Department of Biochemistry & Molecular Biology, Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, 975 NE 10th St., BRC 417, Oklahoma City, OK 73104, USA.
Department of Microbiology and Immunology, University at Buffalo School of Medicine, 347 Biomedical Research Building, 3435 Main Street, Buffalo, NY 14214, USA.
出版信息
Curr Opin Microbiol. 2015 Aug;26:41-7. doi: 10.1016/j.mib.2015.04.006. Epub 2015 May 17.
Abstract
Cells must know the local levels of available oxygen and either adapt accordingly or relocate to more favorable environments. Prolyl 4-hydroxylases (P4Hs) are emerging as universal cellular oxygen sensors. In animals, these oxygen sensors respond to decreased oxygen availability by up-regulating hypoxia-inducible transcription factors. In protozoa, the P4Hs appear to activate E3-SCF ubiquitin ligase complexes via a glycosylation-dependent mechanism, potentially to turn over their proteomes. Intracellular parasites are impacted by both types of oxygen-sensing pathways. Since parasites are exposed to diverse oxygen tensions during their life cycles, this review identifies emerging oxygen-sensing mechanisms and discusses how these mechanisms probably contribute to the regulation of unicellular eukaryotes.
摘要
细胞必须了解局部可利用氧气的水平，并据此进行适应或迁移到更适宜的环境中。脯氨酰4-羟化酶（P4Hs）正逐渐成为通用的细胞氧传感器。在动物中，这些氧传感器通过上调缺氧诱导转录因子来应对氧气供应减少的情况。在原生动物中，P4Hs似乎通过一种糖基化依赖机制激活E3-SCF泛素连接酶复合物，这可能是为了更新它们的蛋白质组。细胞内寄生虫会受到这两种氧感应途径的影响。由于寄生虫在其生命周期中会暴露于不同的氧张力下，本综述确定了新出现的氧感应机制，并讨论了这些机制可能如何对单细胞真核生物的调节产生影响。
相似文献
1
Oxygen sensing by protozoans: how they catch their breath.原生动物的氧气感知：它们如何呼吸
Curr Opin Microbiol. 2015 Aug;26:41-7. doi: 10.1016/j.mib.2015.04.006. Epub 2015 May 17.
2
A Prolyl Hydroxylase Mediates Oxygen Stress Responses by Regulating Translation Elongation.脯氨酰羟化酶通过调节翻译延伸来介导氧应激反应。
mBio. 2019 Mar 26;10(2):e00234-19. doi: 10.1128/mBio.00234-19.
3
An oxygen molecular sensor, the HIF prolyl 4-hydroxylase, in the marine protist Perkinsus olseni.海洋原生生物奥尔森派琴虫中的一种氧分子传感器——低氧诱导因子脯氨酰4-羟化酶。
Protist. 2008 Jul;159(3):355-68. doi: 10.1016/j.protis.2008.03.002. Epub 2008 Jun 9.
4
Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin.氧感应脯氨酰羟化酶通过调节骨保护素调控骨稳态。
Genes Dev. 2015 Apr 15;29(8):817-31. doi: 10.1101/gad.255000.114. Epub 2015 Apr 6.
5
Cellular oxygen sensing need in CNS function: physiological and pathological implications.中枢神经系统功能中细胞氧感应的需求：生理和病理意义
J Exp Biol. 2004 Aug;207(Pt 18):3171-88. doi: 10.1242/jeb.01075.
6
Oxygen-sensing in tumors.肿瘤中的氧感应
Curr Opin Clin Nutr Metab Care. 2006 Jul;9(4):366-78. doi: 10.1097/01.mco.0000232895.28674.79.
7
Mesangial renal disease, oxygen sensing, and prolyl hydroxylase.系膜性肾病、氧感应与脯氨酰羟化酶
J Mol Med (Berl). 2017 Mar;95(3):235-237. doi: 10.1007/s00109-017-1514-8.
8
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.后生动物的氧感应：HIF羟化酶途径的核心作用。
Mol Cell. 2008 May 23;30(4):393-402. doi: 10.1016/j.molcel.2008.04.009.
9
[Characteristics of the signal transduction in parasitic lower eukaryotes].[寄生性低等真核生物中信号转导的特征]
Tsitologiia. 2009;51(11):880-95.
10
Crystal structure and expression patterns of prolyl 4-hydroxylases from Phytophthora capsici.辣椒疫霉脯氨酰 4-羟化酶的晶体结构和表达模式。
Biochem Biophys Res Commun. 2019 Jan 22;508(4):1011-1017. doi: 10.1016/j.bbrc.2018.12.022. Epub 2018 Dec 11.
引用本文的文献
1
Glycosylation Weakens Skp1 Homodimerization in by Interrupting a Fuzzy Interaction.糖基化通过中断模糊相互作用削弱Skp1同二聚化。
Biochemistry. 2025 May 20;64(10):2262-2279. doi: 10.1021/acs.biochem.4c00859. Epub 2025 Apr 29.
2
Distinct Stress Regulators in the CRL Family: Emerging Roles of F-Box Proteins: Cullin-RING Ligases and Stress-Sensing.CRL家族中不同的应激调节因子：F-Box蛋白的新作用：Cullin-RING连接酶与应激感应
Bioessays. 2025 May;47(5):e202400249. doi: 10.1002/bies.202400249. Epub 2025 Mar 16.
3
New insights into the N-glycomes of species.对物种N-糖组的新见解。
BBA Adv. 2025 Jan 16;7:100142. doi: 10.1016/j.bbadva.2025.100142. eCollection 2025.
4
Oxygen-dependent regulation of F-box proteins in Toxoplasma gondii is mediated by Skp1 glycosylation.刚地弓形虫中F-盒蛋白的氧依赖性调节由Skp1糖基化介导。
J Biol Chem. 2024 Nov;300(11):107801. doi: 10.1016/j.jbc.2024.107801. Epub 2024 Sep 21.
5
Understanding the significance of oxygen tension on the biology of Plasmodium falciparum blood stages: From the human body to the laboratory.了解氧张力对恶性疟原虫血期生物学的意义：从人体到实验室。
PLoS Pathog. 2024 Sep 19;20(9):e1012514. doi: 10.1371/journal.ppat.1012514. eCollection 2024 Sep.
6
The Toxoplasma oxygen-sensing protein, TgPhyA, is required for resistance to interferon gamma-mediated nutritional immunity in mice.弓形虫氧感应蛋白 TgPhyA 是小鼠抵抗干扰素 γ 介导的营养免疫所必需的。
PLoS Biol. 2024 Jun 10;22(6):e3002690. doi: 10.1371/journal.pbio.3002690. eCollection 2024 Jun.
7
Synergy between a cytoplasmic vWFA/VIT protein and a WD40-repeat F-box protein controls development in .一种细胞质vWFA/VIT蛋白与一种WD40重复序列F-box蛋白之间的协同作用控制着……的发育。
Front Cell Dev Biol. 2023 Sep 14;11:1259844. doi: 10.3389/fcell.2023.1259844. eCollection 2023.
8
The aerotaxis of is independent of mitochondria, nitric oxide and oxidative stress.[具体事物]的趋氧性独立于线粒体、一氧化氮和氧化应激。 （原文中“of”后缺少具体所指事物）
Front Cell Dev Biol. 2023 Jun 15;11:1134011. doi: 10.3389/fcell.2023.1134011. eCollection 2023.
9
Oxygen-dependent regulation of E3(SCF)ubiquitin ligases and a Skp1-associated JmjD6 homolog in development of the social amoeba Dictyostelium.氧依赖性调节 E3（SCF）泛素连接酶和 Skp1 相关 JmjD6 同源物在社会性阿米巴 Dictyostelium 发育中的作用。
J Biol Chem. 2022 Sep;298(9):102305. doi: 10.1016/j.jbc.2022.102305. Epub 2022 Aug 4.
10
Glycomics, Glycoproteomics, and Glycogenomics: An Inter-Taxa Evolutionary Perspective.糖组学、糖蛋白质组学和糖生物学：跨物种进化视角。
Mol Cell Proteomics. 2021;20:100024. doi: 10.1074/mcp.R120.002263. Epub 2021 Jan 6.
本文引用的文献
1
Glycosylation of Skp1 promotes formation of Skp1-cullin-1-F-box protein complexes in dictyostelium.Skp1的糖基化促进了盘基网柄菌中Skp1-遍在蛋白连接酶E1-泛素连接酶F盒蛋白复合物的形成。
Mol Cell Proteomics. 2015 Jan;14(1):66-80. doi: 10.1074/mcp.M114.044560. Epub 2014 Oct 23.
2
Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.人类的氧感知可能起源于原核生物延伸因子Tu的脯氨酰羟化作用。
Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13331-6. doi: 10.1073/pnas.1409916111. Epub 2014 Sep 2.
3
Regulation of transcription termination by glucosylated hydroxymethyluracil, base J, in Leishmania major and Trypanosoma brucei.利什曼原虫和布氏锥虫中糖基化羟甲基尿嘧啶（碱基J）对转录终止的调控
Nucleic Acids Res. 2014 Sep;42(15):9717-29. doi: 10.1093/nar/gku714. Epub 2014 Aug 7.
4
Respiration in heterotrophic unicellular eukaryotic organisms.异养单细胞真核生物中的呼吸作用。
Protist. 2014 Aug;165(4):485-92. doi: 10.1016/j.protis.2014.05.006. Epub 2014 Jun 10.
5
Toxoplasma gondii development of its replicative niche: in its host cell and beyond.刚地弓形虫复制微环境的形成：在其宿主细胞内及细胞外。
Eukaryot Cell. 2014 Aug;13(8):965-76. doi: 10.1128/EC.00081-14. Epub 2014 Jun 20.
6
Ribosomal oxygenases are structurally conserved from prokaryotes to humans.核糖体加氧酶在从原核生物到人之间具有结构保守性。
Nature. 2014 Jun 19;510(7505):422-426. doi: 10.1038/nature13263. Epub 2014 May 11.
7
Novel regulation of Skp1 by the Dictyostelium AgtA α-galactosyltransferase involves the Skp1-binding activity of its WD40 repeat domain.新型调控 Skp1 的 Dictyostelium AgtA α-半乳糖基转移酶涉及 Skp1 结合活性的其 WD40 重复结构域。
J Biol Chem. 2014 Mar 28;289(13):9076-88. doi: 10.1074/jbc.M113.528679. Epub 2014 Feb 18.
8
Glycosylation of Skp1 affects its conformation and promotes binding to a model f-box protein.Skp1 的糖基化会影响其构象，并促进其与模型 F-box 蛋白的结合。
Biochemistry. 2014 Mar 18;53(10):1657-69. doi: 10.1021/bi401707y. Epub 2014 Mar 3.
9
Globin-coupled heme containing oxygen sensor soluble adenylate cyclase in Leishmania prevents cell death during hypoxia.利什曼原虫中与珠蛋白偶联的含血红素的可溶性环化酶在缺氧时防止细胞死亡。
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16790-5. doi: 10.1073/pnas.1304145110. Epub 2013 Sep 30.
10
Molecular paleontology and complexity in the last eukaryotic common ancestor.分子古生物学与最后真核生物共同祖先中的复杂性。
Crit Rev Biochem Mol Biol. 2013 Jul-Aug;48(4):373-96. doi: 10.3109/10409238.2013.821444.
Zotero 插件