肿瘤代谢：MAGE-A 蛋白帮助 TRIM 翻转 AMPK。

Tumor Metabolism: MAGE-A Proteins Help TRIM Turn Over AMPK.

机构信息

Molecular and Cell Biology Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.

出版信息

Curr Biol. 2015 May 18;25(10):R418-20. doi: 10.1016/j.cub.2015.03.019.

DOI:10.1016/j.cub.2015.03.019

PMID:25989082

Abstract

MAGE-A proteins are testis-specific E3 ubiquitin ligase components whose expression is upregulated in many cancers. MAGE-A3 and -A6 act as oncogenes and recent work now shows that they degrade the central metabolic regulator AMPK, providing a novel mechanism for rewiring cancer metabolism.

摘要

MAGE-A 蛋白是睾丸特异性 E3 泛素连接酶的组成部分，其在许多癌症中表达上调。MAGE-A3 和 -A6 作为癌基因发挥作用，最近的研究表明它们降解了中央代谢调节剂 AMPK，为重新连接癌症代谢提供了一种新的机制。