Yang Meng, Kenfield Stacey A, Van Blarigan Erin L, Wilson Kathryn M, Batista Julie L, Sesso Howard D, Ma Jing, Stampfer Meir J, Chavarro Jorge E
Department of Nutrition, Harvard T.H.Chan School of Public Health, Boston, MA.
Department of Urology, University of California, San Francisco, San Francisco, CA.
Int J Cancer. 2015 Nov 15;137(10):2462-9. doi: 10.1002/ijc.29608. Epub 2015 Jun 3.
Information regarding postdiagnostic dairy intake and prostate cancer survival is limited. We evaluated intake of total, high-fat and low-fat dairy after prostate cancer diagnosis in relation to disease-specific and total mortality. We included 926 men from the Physicians' Health Study diagnosed with non-metastatic prostate cancer between 1982 and 2000 who completed a diet questionnaire a median of 5 years after diagnosis and were followed thereafter for a median of 10 years to assess mortality. Cox proportional hazards regression was used to estimate associations between dairy intake and prostate cancer specific and all-cause mortality. During 8,903 person-years of follow-up, 333 men died, 56 due to prostate cancer. Men consuming ≥3 servings/day of total dairy products had a 76% higher risk of total mortality and a 141% higher risk of prostate cancer-specific mortality compared to men who consumed less than 1 dairy product/day (hazard ratio (HR) = 1.76, 95% confidence interval (CI): 1.21, 2.55, ptrend < 0.001 for total mortality; HR = 2.41, 95% CI: 0.96, 6.02, ptrend = 0.04 for prostate cancer-specific mortality). The association between high-fat dairy and mortality risk appeared to be stronger than that of low-fat dairy, but the difference between them was not statistically significant (p for difference = 0.57 for prostate cancer-specific mortality and 0.56 for total mortality). Among men without metastases when diagnosed, higher intake of dairy foods after prostate cancer diagnosis may be associated with increased prostate cancer-specific and all-cause mortality.
关于前列腺癌诊断后乳制品摄入量与生存情况的信息有限。我们评估了前列腺癌诊断后全脂、高脂和低脂乳制品的摄入量与疾病特异性死亡率和总死亡率的关系。我们纳入了926名来自医生健康研究的男性，他们在1982年至2000年间被诊断为非转移性前列腺癌，在诊断后中位数为5年时完成了一份饮食问卷，此后进行了中位数为10年的随访以评估死亡率。采用Cox比例风险回归来估计乳制品摄入量与前列腺癌特异性死亡率和全因死亡率之间的关联。在8903人年的随访期间，333名男性死亡，其中56人死于前列腺癌。与每天摄入少于1份乳制品的男性相比，每天摄入≥3份全脂乳制品的男性总死亡率风险高76%，前列腺癌特异性死亡率风险高141%（风险比（HR）=1.76，95%置信区间（CI）：1.21，2.55，总死亡率的ptrend＜0.001；HR = 2.41，95%CI：0.96，6.02，前列腺癌特异性死亡率的ptrend = 0.04）。高脂乳制品与死亡风险之间的关联似乎比低脂乳制品更强，但两者之间的差异无统计学意义（前列腺癌特异性死亡率差异的p值 = 0.57，总死亡率差异的p值 = 0.56）。在诊断时无转移的男性中，前列腺癌诊断后较高的乳制品摄入量可能与前列腺癌特异性死亡率和全因死亡率增加有关。
