Charlot Keyne, Moeckesch Berenike, Jumet Stéphane, Romana Marc, Waltz Xavier, Divialle-Doumdo Lydia, Hardy-Dessources Marie-Dominique, Petras Marie, Tressières Benoît, Pichon Aurélien, Tarer Vanessa, Hue Olivier, Etienne-Julan Maryse, Antoine-Jonville Sophie, Connes Philippe
UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France.
Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France.
Pediatr Blood Cancer. 2015 Nov;62(11):1962-7. doi: 10.1002/pbc.25604. Epub 2015 May 19.
Autonomic nervous system (ANS) activity has been suggested to modulate the clinical severity of sickle cell anemia (SCA) by increasing the risk for vaso-occlusive events. Regular physical activity (PA) is known to improve ANS activity and health status in several cardiovascular and metabolic diseases. Whether regular PA improves the health status of SCA patients remains unknown.
Twenty-two patients with SCA and 15 healthy (AA) children/adolescents participated to the study. Heart rate variability was measured in supine position and after a tilt-test to quantify the ANS activity. PA energy expenditure (PAEE) was assessed with questionnaire.
Both the level of PA and ANS activity are reduced in SCA compared to AA children/adolescents, particularly in those older than 15 years. Neither PAEE, nor ANS activity seem to influence the clinical severity of children/adolescents with SCA.
自主神经系统（ANS）活动被认为通过增加血管闭塞性事件的风险来调节镰状细胞贫血（SCA）的临床严重程度。已知规律的体育活动（PA）可改善多种心血管和代谢疾病中的自主神经系统活动及健康状况。规律的体育活动是否能改善SCA患者的健康状况仍不清楚。
22例SCA患者和15名健康（AA）儿童/青少年参与了该研究。在仰卧位和倾斜试验后测量心率变异性，以量化自主神经系统活动。通过问卷评估体育活动能量消耗（PAEE）。
1）与AA组相比，SCA组的PAEE较低（分别为190±152与432±277千卡·天⁻¹，P<0.01）；2）与AA组相比，SCA组的总体自主神经系统活动较低；3）在SCA患者中观察到随着年龄增长副交感神经活动减退；4）与AA组相比，SCA组的自主神经系统反应性略有受损（高频功率降低：分别为-38±27%与-58±14%，P<0.05）；5）自主神经系统指标、PAEE和临床事件发生率无相关性。
与AA儿童/青少年相比，SCA患者的体育活动水平和自主神经系统活动均降低，尤其是15岁以上者。体育活动能量消耗和自主神经系统活动似乎均不影响SCA儿童/青少年的临床严重程度。
