Hedreville Mona, Charlot Keyne, Waltz Xavier, Sinnapah Stéphane, Lemonne Nathalie, Etienne-Julan Maryse, Soter Valérie, Hue Olivier, Hardy-Dessources Marie-Dominique, Barthélémy Jean-Claude, Connes Philippe
Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France; Emergency Care Department, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France.
Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France; UMR Inserm U1134 French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France; Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
PLoS One. 2014 Apr 16;9(4):e95563. doi: 10.1371/journal.pone.0095563. eCollection 2014.
A decreased global autonomic nervous system (ANS) activity and increased sympathetic activation in patients with sickle cell anemia (SCA) seem to worsen the clinical severity and could play a role in the pathophysiology of the disease, notably by triggering vaso-occlusive crises. Because exercise challenges the ANS activity in the general population, we sought to determine whether a short (<15 min) and progressive moderate exercise session conducted until the first ventilatory threshold had an effect on the ANS activity of a group of SCA patients and a group of healthy individuals (CONT group). Temporal and spectral analyses of the nocturnal heart rate variability were performed before and on the 3 nights following the exercise session. Standard deviation of all normal RR intervals (SDNN), total power, low frequencies (LF) and high frequencies powers (HF) were lower but LF/HF was higher in SCA patients than in the CONT group. Moderate exercise did not modify ANS activity in both groups. In addition, no adverse clinical events occurred during the entire protocol. These results imply that this kind of short and moderate exercise is not detrimental for SCA patients.
镰状细胞贫血（SCA）患者的整体自主神经系统（ANS）活动降低以及交感神经激活增加似乎会加重临床严重程度，并可能在该疾病的病理生理学中起作用，特别是通过引发血管阻塞性危机。由于运动对一般人群的ANS活动有挑战，我们试图确定进行至首次通气阈值的短时间（<15分钟）渐进性适度运动对一组SCA患者和一组健康个体（对照组）的ANS活动是否有影响。在运动前及运动后的3个晚上进行夜间心率变异性的时域和频域分析。SCA患者的所有正常RR间期标准差（SDNN）、总功率、低频（LF）和高频功率（HF）均低于对照组，但LF/HF高于对照组。适度运动在两组中均未改变ANS活动。此外，在整个方案期间未发生不良临床事件。这些结果表明，这种短时间适度运动对SCA患者无害。
