Li Zhaofei, Cao Lihua, Fan Mingwen, Xu Qingan
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine of Ministry of Education (KLOBM), School and Hospital of Stomatology, Wuhan University, Wuhan, China.
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine of Ministry of Education (KLOBM), School and Hospital of Stomatology, Wuhan University, Wuhan, China; Department of Endodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
J Endod. 2015 Sep;41(9):1412-7. doi: 10.1016/j.joen.2015.04.012. Epub 2015 May 16.
The purpose of this study was to compare the effectiveness of mineral trioxide aggregate (MTA) and calcium hydroxide (CH) as pulp capping materials in humans by means of a meta-analysis.
The PubMed, Cochrane Library, Embase, and Web of Knowledge databases were used in the literature search from their establishment date until December 7, 2014. Studies that met the inclusion criteria were accepted, and necessary information was extracted by 2 authors independently using a standardized form. The success rate, inflammatory response, and dentin bridge formation were evaluated.
Thirteen studies met the inclusion criteria. There was no significant heterogeneity between studies, so a fixed-effects model was used. The MTA treatment groups showed a significantly higher success rate compared with CH-capped groups (randomized controlled trials: odds ratio [OR] = 2.26; 95% confidence interval [CI] = 1.33-3.85; P = .003; retrospective nonrandomized trials: OR = 2.88; 95% CI, 1.86-4.44; P < .00001). MTA was superior to CH in terms of the absence of an inflammatory response as well as dentin bridge formation, with the OR being 4.56 (95% CI, 2.65-7.83) and 3.56 (95% CI, 1.89-6.70), respectively.
MTA has a higher success rate and results in less pulpal inflammatory response and more predictable hard dentin bridge formation than CH. MTA appears to be a suitable replacement of CH used for direct pulp capping.
本研究的目的是通过荟萃分析比较矿物三氧化物凝聚体（MTA）和氢氧化钙（CH）作为人类牙髓盖髓材料的有效性。
使用PubMed、Cochrane图书馆、Embase和Web of Knowledge数据库进行文献检索，检索时间范围从数据库建立至2014年12月7日。符合纳入标准的研究被纳入，两名作者独立使用标准化表格提取必要信息。评估成功率、炎症反应和牙本质桥形成情况。
13项研究符合纳入标准。各研究间无显著异质性，因此采用固定效应模型。与CH盖髓组相比，MTA治疗组显示出显著更高的成功率（随机对照试验：优势比[OR]=2.26；95%置信区间[CI]=1.33 - 3.85；P = 0.003；回顾性非随机试验：OR = 2.88；95% CI，1.86 - 4.44；P < 0.00001）。在无炎症反应以及牙本质桥形成方面，MTA优于CH，OR分别为4.56（95% CI，2.65 - 7.83）和3.56（95% CI，1.89 - 6.70）。
与CH相比，MTA具有更高的成功率，导致牙髓炎症反应更少，硬组织牙本质桥形成更可预测。MTA似乎是用于直接盖髓的CH的合适替代品。
