抗CCL2：构建转移的“蓄水池”还是打开转移的“闸门”？
Anti-CCL2: building a reservoir or opening the floodgates to metastasis?
作者信息
Hitchcock Jessica R, Watson Christine J
机构信息
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.
出版信息
Breast Cancer Res. 2015 May 21;17(1):68. doi: 10.1186/s13058-015-0573-4.
Abstract
Neutralisation of macrophage chemoattractant C-C chemokine ligand 2 (CCL2) has shown reduced metastasis and enhanced survival in numerous experimental models of tumorigenesis. However, important new findings reported in Nature by Momo Bentires-Alj's laboratory demonstrate that withdrawal of anti-CCL2 treatment accelerates lung metastasis and death in mice. The study highlights the need to consider longer term consequences of therapeutic intervention of metastatic disease, especially with regard to transient interference with the tumour microenvironment.
摘要
在众多肿瘤发生的实验模型中，巨噬细胞趋化因子C-C趋化因子配体2（CCL2）的中和已显示出转移减少和生存期延长。然而，莫莫·本蒂雷斯-阿尔吉实验室在《自然》杂志上报道的重要新发现表明，停止抗CCL2治疗会加速小鼠的肺转移和死亡。该研究强调，需要考虑转移性疾病治疗干预的长期后果，尤其是对肿瘤微环境的短暂干扰。
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本文引用的文献
1
Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis.
Nature. 2014 Nov 6;515(7525):130-3. doi: 10.1038/nature13862. Epub 2014 Oct 22.
2
A role for CCL2 in both tumor progression and immunosurveillance.
Oncoimmunology. 2013 Jul 1;2(7):e25474. doi: 10.4161/onci.25474.
3
Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic γδ T lymphocytes to tumor beds.
J Immunol. 2013 Jun 15;190(12):6673-80. doi: 10.4049/jimmunol.1300434. Epub 2013 May 17.
4
Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells.
PLoS One. 2013;8(3):e58791. doi: 10.1371/journal.pone.0058791. Epub 2013 Mar 18.
5
A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors.
Cancer Chemother Pharmacol. 2013 Apr;71(4):1041-50. doi: 10.1007/s00280-013-2099-8. Epub 2013 Feb 6.
6
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis.
Nature. 2011 Jun 8;475(7355):222-5. doi: 10.1038/nature10138.
7
Monocyte chemoattractant protein-1 blockade inhibits lung cancer tumor growth by altering macrophage phenotype and activating CD8+ cells.
Am J Respir Cell Mol Biol. 2011 Feb;44(2):230-7. doi: 10.1165/rcmb.2010-0080OC. Epub 2010 Apr 15.
8
Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression.
Int J Cancer. 2009 Sep 15;125(6):1276-84. doi: 10.1002/ijc.24378.
9
Microenvironmental regulation of metastasis.
Nat Rev Cancer. 2009 Apr;9(4):239-52. doi: 10.1038/nrc2618. Epub 2008 Mar 12.
10
Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo.
Cancer Res. 2007 Oct 1;67(19):9417-24. doi: 10.1158/0008-5472.CAN-07-1286.
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