Fawzy Muhammad, Mesbah Yasser
Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Arch Gynecol Obstet. 2015 Dec;292(6):1267-71. doi: 10.1007/s00404-015-3755-5. Epub 2015 May 20.
To compare the efficacy of the oral dienogest versus triptorelin acetate injection for treatment of premenopausal menorrhagia and pelvic pains in women with uterine adenomyosis.
A total of 41 patients with adenomyosis suffering from pelvic pains and menorrhagia were recruited. First group was managed with oral dienogest (2 mg/day, orally) while the second group received triptorelin acetate (3.75 mg/4 weeks, subcutaneous injection) for 16 weeks. Outpatient follow-up was undertaken after 8 weeks but mean values were calculated at baseline and after 16 weeks (end of treatment).
A total of 41 women were allocated to treatment with dienogest (n = 22) or triptorelin acetate (n = 19); 19 (86.4 %) and 18 (94.7 %) % of the respective groups completed the trial. Significant reductions in pelvic pains after 16 weeks treatment were obtained in both groups demonstrating the equivalence of dienogest relative to triptorelin acetate. Triptorelin acetate was more effective in controlling of menorrhagia and reduction of uterine volume.
Dienogest may be a valuable alternative to depot triptorelin acetate for treatment of premenopausal pelvic pains in women with uterine adenomyosis.
比较口服地诺孕素与醋酸曲普瑞林注射治疗子宫腺肌病所致绝经前月经过多和盆腔疼痛的疗效。
共招募41例患有盆腔疼痛和月经过多的子宫腺肌病患者。第一组采用口服地诺孕素（2毫克/天，口服）治疗，而第二组接受醋酸曲普瑞林（3.75毫克/4周，皮下注射）治疗，为期16周。8周后进行门诊随访，但在基线时和16周后（治疗结束时）计算平均值。
共有41名女性被分配接受地诺孕素（n = 22）或醋酸曲普瑞林（n = 19）治疗；相应组中分别有19名（86.4%）和18名（94.7%）完成试验。两组在治疗16周后盆腔疼痛均显著减轻，表明地诺孕素与醋酸曲普瑞林等效。醋酸曲普瑞林在控制月经过多和减小子宫体积方面更有效。
对于治疗子宫腺肌病所致绝经前盆腔疼痛，地诺孕素可能是醋酸曲普瑞林长效注射剂的一种有价值的替代药物。
