通过医院出院记录估算成年人重症肌无力的发病率、患病率和诊断年龄。

Estimation of incidence, prevalence, and age-at-diagnosis of myasthenia gravis among adults by hospital discharge records.

作者信息

Foldvari Anett, Kovacs Nora, Sipos Valeria, Merth Gabriella, Vincze Ferenc, Szucs Maria, Sandor Janos

机构信息

Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, PO Box 2, 4012, Debrecen, Hungary.

出版信息

Wien Klin Wochenschr. 2015 Jun;127(11-12):459-64. doi: 10.1007/s00508-015-0796-5. Epub 2015 May 20.

DOI:10.1007/s00508-015-0796-5

PMID:25990531

Abstract

BACKGROUND

The Hungarian Health Insurance Fund, using appropriate information technology, covers all of the secondary care of the country and maintains a database of Hospital Discharge Records (HDR). Our study aimed to determine the incidence, average age-at-diagnosis (AaD), and prevalence of myasthenia gravis (MG) among adults and the regional heterogeneity of these measures to assess the potential usefulness of HDRs for monitoring.

METHODS

The nationwide database of 336,679 HDRs from 2004 to 2009 was analyzed. The incidence and prevalence were determined for adults in 2007. Patients with MG code in 2007, 2008, and 2009 but without that in 2004-2006 were defined as incident. Distribution of AaD was described for these cases. Patients with an MG code in 2007, 2008, and 2009 were defined as prevalent in 2007. The heterogeneity of regional age-standardized indices was tested.

RESULTS

The observed incidence and prevalence was 2.76/100,000 (men: 2.37/100,000; women: 3.11/100,000) and 17.42/100,000 (male: 13.08/100,000; female: 21.28/100,000), respectively. These estimates were within published ranges. The mean AaD was significantly higher for men than for women (63.60 vs. 51.92; p < 0.001). Significant regional heterogeneity was observed for all measures.

CONCLUSIONS

HDRs seem to be useful for developing MG indicators because they adequately estimate epidemiological parameters of MG occurrence.

摘要

背景

匈牙利健康保险基金利用适当的信息技术覆盖了该国所有的二级医疗服务，并维护了一个医院出院记录（HDR）数据库。我们的研究旨在确定成年人重症肌无力（MG）的发病率、平均诊断年龄（AaD）和患病率，以及这些指标的区域异质性，以评估HDRs用于监测的潜在效用。

方法

分析了2004年至2009年全国范围内336,679份HDRs的数据库。确定了2007年成年人的发病率和患病率。2007年、2008年和2009年有MG编码但2004 - 2006年没有的患者被定义为新发病例。描述了这些病例的AaD分布情况。2007年、2008年和2009年有MG编码的患者被定义为2007年的现患病例。测试了区域年龄标准化指数的异质性。

结果

观察到的发病率和患病率分别为2.76/100,000（男性：2.37/100,000；女性：3.11/100,000）和17.42/100,000（男性：13.08/100,000；女性：21.28/100,000）。这些估计值在已发表的范围内。男性的平均AaD显著高于女性（63.60对51.92；p < 0.001）。所有指标均观察到显著的区域异质性。