Zivadinov R, Jurjevic A, Willheim K, Cazzato G, Zorzon M
Neurological Clinics, University of Rijeka, Croatia.
Neuroepidemiology. 1998;17(5):265-72. doi: 10.1159/000026179.
For the period 1976 through 1996, we carried out an incidence and prevalence study of myasthenia gravis in the County of the Coast and Gorski kotar, Croatia. This was the first epidemiological study of myasthenia gravis in Croatia. A total of 43 incident cases were identified. Overall the average crude annual incidence rate was 6.52 per 1,000,000 person-years; 5.59 per 1,000,000 person-years for men and 7.41 per 1,000,000 person-years for women. The incidence rate was 6.30 (95% confidence intervals 4.56-8.51), age-adjusted to the European population and 5.17 (95% confidence intervals 3.74-6.98), age-adjusted to the world population. On 31 December 1996, there were 32 prevalent cases. The crude prevalence was 99 per 1,000,000 population (95% confidence intervals 67.7-139.6). The prevalence adjusted to the European and world populations was 101.9 (95% confidence intervals 69.7-143.7) and 75.9 (95% confidence intervals 51.9-107) per 1,000,000 population, respectively. Our incidence findings are similar to those reported in North-East Italy but lower than those in the United States. Our prevalence findings were generally higher than those in Northern European Countries but lower than those in the United States. Standardization of rates to the European or world population could facilitate comparison between different populations.
1976年至1996年期间，我们在克罗地亚的海岸县和戈尔斯基科塔尔开展了一项重症肌无力的发病率和患病率研究。这是克罗地亚首次对重症肌无力进行的流行病学研究。共确定了43例新发病例。总体而言，平均粗年发病率为每100万人年6.52例；男性为每100万人年5.59例，女性为每100万人年7.41例。年龄调整后，欧洲人口的发病率为6.30（95%置信区间4.56 - 8.51），世界人口的发病率为5.17（95%置信区间3.74 - 6.98）。1996年12月31日，有32例现患病例。粗患病率为每100万人口99例（95%置信区间67.7 - 139.6）。调整后，欧洲和世界人口的患病率分别为每100万人口101.9例（95%置信区间69.7 - 143.7）和75.9例（95%置信区间51.9 - 107）。我们的发病率研究结果与意大利东北部报告的结果相似，但低于美国。我们的患病率研究结果总体上高于北欧国家，但低于美国。将发病率标准化到欧洲或世界人口可以便于不同人群之间的比较。
