Dai Chuan-Fang, Xie Xiang, Ma Yi-Tong, Yang Yi-Ning, Li Xiao-Mei, Fu Zhen-Yan, Liu Fen, Chen Bang-Dang, Gai Min-Tao
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China.
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China
J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):1314-20. doi: 10.1177/1470320315585683. Epub 2015 May 18.
With the development of genome-wide association studies (GWAS) concerning hypertension, a growing number of susceptibility genes related to hypertension have been revealed. Subsequently, several studies have investigated the association between CYP17A1 rs1004467 heritable variation and hypertension; however, the results have been inconsistent. In this study, a meta-analysis was performed to assess the association between the CYP17A1 rs1004467 polymorphism and hypertension risk.
The PubMed, ISI Web of Science and Embase databases as well as China Wanfang, Weipu and the Chinese Journal Full-text Database were used to retrieve all publications from 2005 to 2013 related to case-control studies that reported a link between the risk factors for hypertension and the CYP17A1 polymorphism. All association studies were identified, and a meta-analysis was conducted using the RevMan 5.0 estimate for odds ratios (ORs) to determine whether the A allele predicts hypertension outcomes.
Three articles including five studies (totaling 4495 patients and 3529 controls) were identified. The overall effect suggested that rs1004467 was significantly associated with hypertension (OR=1.22, 95%CI 1.08-1.38, p=0.001).
The present meta-analysis confirmed the significant association between a polymorphism of the CYP17A1 gene and hypertension susceptibility. The CYP17A1 A allele should be considered a risk factor for hypertension.
随着全基因组关联研究（GWAS）在高血压领域的开展，越来越多与高血压相关的易感基因被发现。随后，多项研究对CYP17A1基因rs1004467位点的遗传变异与高血压之间的关联进行了探究；然而，研究结果并不一致。本研究通过荟萃分析评估CYP17A1基因rs1004467多态性与高血压风险之间的关联。
利用PubMed、ISI Web of Science和Embase数据库以及中国万方、维普和中国期刊全文数据库，检索2005年至2013年期间所有与病例对照研究相关的文献，这些研究报告了高血压危险因素与CYP17A1基因多态性之间的联系。识别所有关联研究，并使用RevMan 5.0软件对优势比（OR）进行荟萃分析，以确定A等位基因是否可预测高血压结局。
共纳入3篇文章，包含5项研究（总计4495例患者和3529例对照）。总体效应表明，rs1004467与高血压显著相关（OR=1.22，95%CI 1.08 - 1.38，p=0.001）。
本荟萃分析证实了CYP17A1基因多态性与高血压易感性之间存在显著关联。CYP17A1基因的A等位基因应被视为高血压的一个危险因素。
