Murofushi Toshihisa, Komiyama Sakurako, Hayashi Yushi, Yoshimura Eriko
Department of Otolaryngology, Teikyo University School of Medicine, Mizonokuchi Hospital , Kawasaki , Japan.
Acta Otolaryngol. 2015;135(10):995-9. doi: 10.3109/00016489.2015.1022834. Epub 2015 May 19.
Idiopathic otolithic vertigo (IOV) with relatively long duration of attacks might be caused by endolymphatic hydrops in the otolith organ.
To clarify the pathophysiology underlying IOV, episodic tilting or translational sensation attacks by unknown causes, especially the possibility of endolymphatic hydrops in the otolith organ.
Sixteen patients (6 men and 10 women) diagnosed with having IOV were enrolled. In these subjects, frequency preference in cervical vestibular evoked myogenic potential (cVEMP) was studied. The subjects underwent cVEMP testing using 500 Hz and 1000 Hz short tone bursts (STB) (125 dB SPL, air-conducted sound). The 500-1000 Hz cVEMP slope was calculated and assessed in comparison with data from healthy subjects in the preceding study.
Twelve of the 16 examined patients had a significant preference of 1000 Hz to 500 Hz, which was suggestive of endolymphatic hydrops in the saccule. Patients with frequency preference of 1000 Hz to 500 Hz showed a tendency for longer vertigo attacks than patients without preference of 1000 Hz.
发作持续时间相对较长的特发性耳石性眩晕（IOV）可能由耳石器官内的内淋巴积水引起。
阐明IOV（原因不明的发作性倾斜或平移感觉发作）的病理生理学，尤其是耳石器官内出现内淋巴积水的可能性。
纳入16例被诊断为IOV的患者（6例男性和10例女性）。对这些受试者研究了颈前庭诱发肌源性电位（cVEMP）的频率偏好。受试者使用500 Hz和1000 Hz短纯音猝发声（STB）（125 dB SPL，气导声音）进行cVEMP测试。计算并评估500 - 1000 Hz的cVEMP斜率，并与先前研究中健康受试者的数据进行比较。
16例受检患者中有12例对1000 Hz的偏好明显高于500 Hz，这提示球囊内存在内淋巴积水。1000 Hz对500 Hz有频率偏好的患者，其眩晕发作倾向于比无1000 Hz偏好的患者持续时间更长。
