Murofushi Toshihisa, Tsubota Masahito, Suizu Ryota, Yoshimura Eriko
Department of Otolaryngology, Teikyo University School of Medicine Mizonokuchi Hospital, Kawasaki, Japan.
Yoshimura ENT Clinic, Fujisawa, Japan.
Front Neurol. 2017 May 8;8:193. doi: 10.3389/fneur.2017.00193. eCollection 2017.
The aim of this study is to show sensitivity and specificity of cervical vestibular-evoked myogenic potential (cVEMP) tuning property test to Ménière's disease (MD) in comparison with healthy controls (HC) and patients with other vestibular diseases.
Totally 92 subjects (50 women and 42 men, 20-77 years of age) were enrolled in this study. Subjects were composed of 38 definite unilateral MD patients, 11 unilateral benign paroxysmal positional vertigo patients, 14 vestibular migraine patients, 19 unilateral vestibular neuritis patients, and 10 HC.
The subjects underwent cVEMP testing to 500 and 1,000 Hz short tone bursts (125 dBSPL). The corrected amplitudes of the first biphasic responses (p13-n23) (cVEMP) were measured. Then, a tuning property index (the 500-1,000 Hz cVEMP slope) was calculated.
The area of under the ROC curve (AUC) was 0.75 in comparison with other vestibular disease patients, while AUC was 0.77 in comparison with other vestibular disease patients plus HC. The best cutoff point of the 500-1,000 Hz cVEMP slope was -19.9. Sensitivity of the tuning property test to MD was 0.74, while specificity was 0.76 to other vestibular disease patients.
The tuning property test of cVEMP is useful as a screening test of MD.
本研究旨在比较颈前庭诱发肌源性电位（cVEMP）调谐特性测试对梅尼埃病（MD）与健康对照者（HC）及其他前庭疾病患者的敏感性和特异性。
本研究共纳入92名受试者（50名女性和42名男性，年龄20 - 77岁）。受试者包括38例明确的单侧MD患者、11例单侧良性阵发性位置性眩晕患者、14例前庭性偏头痛患者、19例单侧前庭神经炎患者和10名HC。
受试者接受针对500和1000Hz短声刺激（125dBSPL）的cVEMP测试。测量第一个双相反应（p13 - n23）（cVEMP）的校正幅度。然后，计算调谐特性指数（500 - 1000Hz cVEMP斜率）。
与其他前庭疾病患者相比，ROC曲线下面积（AUC）为0.75，而与其他前庭疾病患者加HC相比，AUC为0.77。500 - 1000Hz cVEMP斜率的最佳截断点为 - 19.9。调谐特性测试对MD的敏感性为0.74，对其他前庭疾病患者的特异性为0.76。
cVEMP的调谐特性测试可作为MD的筛查测试。
