Yoshiura K, Kanda S
Dentomaxillofac Radiol. 1989 Feb;18(1):25-30. doi: 10.1259/dmfr.18.1.2599236.
Sialoadenitis was induced experimentally in mouse parotid glands and the changes in gland morphology analysed over a period of 60 days by means of quantitative microsialography and histology. The microsialogram was digitized as an intensity histogram and the glands evaluated for seven histomorphometric parameters involving both the acini and duct systems. Differences in the intensity-histogram between experimental and control glands were shown to represent changes in duct architecture in the presence of inflammation, while differences in the relative frequency of pixels between low- and high-intensity areas were found to be due to a decrease in intralobular duct size, and acinar size and number in the former compared with an increase in the major duct components in the latter.
通过定量显微唾液造影术和组织学方法，在小鼠腮腺中实验性诱发涎腺炎，并在60天的时间内分析腺体形态的变化。显微唾液造影图被数字化为强度直方图，并对腺体的七个组织形态计量学参数进行评估，这些参数涉及腺泡和导管系统。实验腺体和对照腺体之间强度直方图的差异表明在存在炎症的情况下导管结构发生了变化，而低强度和高强度区域之间像素相对频率的差异被发现是由于小叶内导管尺寸、腺泡尺寸和数量减少，而后者的主导管成分增加。
