Szatmari P, Bartolucci G, Bremner R
Chedoke-McMaster Hospitals, Hamilton, Ontario.
Dev Med Child Neurol. 1989 Dec;31(6):709-20. doi: 10.1111/j.1469-8749.1989.tb04066.x.
The authors compared children with Asperger syndrome (AS) with high-functioning autistic children and psychiatric outpatient controls on measures of early history and outcome. In terms of their early history, the autistic probands showed more social impairment, a higher frequency of echolalia and pronoun reversal, and a more restricted range of activities than the AS group. Cluster analysis suggested refinements to the diagnostic criteria, which resulted in larger differences between the groups on these early history measures. In terms of their outcome, the autistic probands spent more time in special education classes but developed fewer accessory psychiatric symptoms than the AS children. It was clear, however, that there were no substantive, qualitative differences between the AS and autistic groups, indicating that AS should be considered a mild form of high-functioning autism. The inclusion of AS among the autistic spectrum of disorders has implications both for aetiological studies and for prevalence estimates of the pervasive developmental disorders.
作者将患有阿斯伯格综合征（AS）的儿童与高功能自闭症儿童以及精神科门诊对照儿童在早期病史和预后方面进行了比较。就早期病史而言，自闭症先证者比AS组表现出更多的社交障碍、更高频率的模仿言语和代词反转，以及更受限的活动范围。聚类分析建议对诊断标准进行细化，这导致两组在这些早期病史指标上的差异更大。就预后而言，自闭症先证者在特殊教育班级花费的时间更多，但出现的附加精神症状比AS儿童少。然而，很明显，AS组和自闭症组之间没有实质性的、定性的差异，这表明AS应被视为高功能自闭症的一种轻度形式。将AS纳入自闭症谱系障碍对病因学研究和广泛性发育障碍的患病率估计都有影响。
