Child Neuropsychiatry Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, Hospital Polyclinic of Bari, University of "Aldo Moro" Bari, Piazza Giulio Cesare 1, 70100, Bari, Italy.
Medical Statistic, Department of Biomedical Science and Human Oncology, University of "Aldo Moro" Bari, Bari, Italy.
J Autism Dev Disord. 2019 Jan;49(1):138-150. doi: 10.1007/s10803-018-3689-4.
Since Hans Asperger's first description (Arch Psych Nervenkrankh 117:76-136, 1944), through Lorna Wing's translation and definition (Psychol Med 11:115-129, 1981), to its introduction in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM, 1994), Asperger Syndrome has always aroused huge interest and debate, until vanishing in the DSM fifth edition (2013). The debate regarded its diagnostic validity and its differentiation from high functioning autism (HFA). The present study aimed to examine whether AS differed from HFA in clinical profiles and to analyze the impact of DSM-5's innovation. Differences in cognitive, language, school functioning and comorbidities, were revealed when 80 AS and 70 HFA patients (3-18 years) were compared. Results suggested that an AS empirical distinction within autism spectrum disorder should be clinically useful.
自汉斯·阿斯伯格（Hans Asperger）的首次描述（《心理神经精神病学档案》117：76-136，1944 年），经洛娜·温（Lorna Wing）翻译和定义（《心理医学》11：115-129，1981 年），再到其在《精神障碍诊断与统计手册》第四版（DSM，1994 年）中的引入，阿斯伯格综合征一直引起了巨大的兴趣和争议，直到它在 DSM 第五版（2013 年）中消失。这场争论涉及到其诊断的有效性及其与高功能自闭症（HFA）的区别。本研究旨在检验 AS 是否在临床特征上与 HFA 存在差异，并分析 DSM-5 的创新所带来的影响。通过比较 80 名 AS 和 70 名 HFA 患者（3-18 岁），我们发现了认知、语言、学业功能和共病方面的差异。结果表明，在自闭症谱系障碍内对 AS 进行经验性区分可能具有临床意义。
