van der Meulen Stef A J, Helms Gesa, Dogterom Marileen
FOM Institute AMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands.
J Phys Condens Matter. 2015 Jun 17;27(23):233101. doi: 10.1088/0953-8984/27/23/233101. Epub 2015 May 20.
In this report we review the possibilities of using colloids with surface mobile linkers for the study of colloidal self-assembly processes. A promising route to create systems with mobile linkers is the use of lipid (bi-)layers. These lipid layers can be either used in the form of vesicles or as coatings for hard colloids and emulsion droplets. Inside the lipid bilayers molecules can be inserted via membrane anchors. Due to the fluidity of the lipid bilayer, the anchored molecules remain mobile. The use of different lipid mixtures even allows creating Janus-like particles that exhibit directional bonding if linkers are used which have a preference for a certain lipid phase. In nature mobile linkers can be found e.g. as receptors in cells. Therefore, towards the end of the review, we also briefly address the possibility of using colloids with surface mobile linkers as model systems to mimic cell-cell interactions and cell adhesion processes.
在本报告中，我们回顾了使用带有表面可移动连接体的胶体来研究胶体自组装过程的可能性。创建具有可移动连接体系统的一条有前景的途径是使用脂质（双）层。这些脂质层既可以以囊泡的形式使用，也可以作为硬胶体和乳液滴的涂层。在脂质双层内部，分子可以通过膜锚定物插入。由于脂质双层的流动性，锚定的分子保持可移动性。使用不同的脂质混合物甚至可以制造出类似两面神的粒子，如果使用对特定脂质相有偏好的连接体，这些粒子会表现出定向键合。在自然界中，可移动连接体例如可以作为细胞中的受体被发现。因此，在综述的结尾，我们还简要探讨了使用带有表面可移动连接体的胶体作为模型系统来模拟细胞间相互作用和细胞黏附过程的可能性。
