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[小鼠t单倍型互补的遗传分析]

[Genetic analysis of complementation of t-haplotypes in mice].

作者信息

Safronova L D, Shustrova I V, Orlov V N, Mitrofanov V G

出版信息

Genetika. 1989 Sep;25(9):1619-25.

PMID:2599374
Abstract

Complementation for viability of the compounds tx/ty in complete lethal haplotypes t6, t12, tw5, tw12, tw18, tw73, twPa-1 belonging to the seven basic complementation groups was studied. In the overwhelming majority of crosses a lack of tx/ty offspring was revealed but there is also evidence of non-complete complementation of the tx/ty haplotypes, except for T/tw73XT/tw12, T/tw18XT/t12, T/tw73XT/tw18 crosses in which the level of complementation for viability exceeds 100%. The maternal effect for compound variability was significantly revealed in 9 out of the 19 matings. In addition, reciprocal matings of heterozygotes T/txXT/ty were tested for fertility. In two cases, the maternal effect was also revealed for this character. Comparison of data on viability of the compounds and the fertility of the original strains gives grounds to believe that the tx/ty haplotypes are not completely recessive and partially manifest themselves in the heterozygotes, decreasing fertility in a number of matings. In some cases, these t-haplotypes yield an effect, close to negative complementation, which may be associated with the interaction of the proteins of t-haplotypes.

摘要

研究了属于七个基本互补群的完全致死单倍型t6、t12、tw5、tw12、tw18、tw73、twPa-1中化合物tx/ty的生存力互补情况。在绝大多数杂交中,未发现tx/ty后代,但也有证据表明tx/ty单倍型存在不完全互补,除了T/tw73×T/tw12、T/tw18×T/t12、T/tw73×T/tw18杂交,其生存力互补水平超过100%。在19次交配中的9次中,显著发现了化合物变异性的母体效应。此外,对杂合子T/tx×T/ty的正反交进行了育性测试。在两个案例中,该性状也发现了母体效应。比较化合物生存力数据和原始菌株的育性数据有理由相信,tx/ty单倍型并非完全隐性,在杂合子中部分表现出来,在一些交配中降低了育性。在某些情况下,这些t-单倍型产生的效应接近负互补,这可能与t-单倍型蛋白质的相互作用有关。

相似文献

1
[Genetic analysis of complementation of t-haplotypes in mice].[小鼠t单倍型互补的遗传分析]
Genetika. 1989 Sep;25(9):1619-25.
2
[Genetic analysis of fertility of male mice with various t-haplotypes].[不同t单倍型雄性小鼠生育力的遗传分析]
Genetika. 1989 Oct;25(10):1836-42.
3
[Effect of an increased radiation background on mice, carrying lethal t-haplotypes].
Genetika. 1998 May;34(5):682-7.
4
[Disturbance of the relationship of transmission in male mice carrying the translocation Rb(8,17)1 Iem in combination with t-haplotypes].[携带易位Rb(8,17)1 Iem与t-单倍型相结合的雄性小鼠中传递关系的紊乱]
Genetika. 1993 Dec;29(12):1992-9.
5
[Factors affecting complementation in compounds of the T-locus lethal haplotypes of the house mouse].
Dokl Akad Nauk SSSR. 1982;267(3):753-5.
6
Recessive lethal t haplotypes increase the frequency of the partial trisomy of chromosome 17 (including the T-t complex) among offspring of T(16;17)43H female mice.隐性致死t单倍型会增加T(16;17)43H雌性小鼠后代中17号染色体部分三体(包括T-t复合体)的频率。
Folia Biol (Praha). 1986;32(1):26-35.
7
Sperm from mice carrying one or two t haplotypes are deficient in investment and oocyte penetration.携带一个或两个t单倍型的小鼠精子在受精投入和卵母细胞穿透方面存在缺陷。
Dev Biol. 1995 Mar;168(1):138-49. doi: 10.1006/dbio.1995.1067.
8
Gene mapping within the T/t complex of the mouse. III: t-Lethal genes are arranged in three clusters on chromosome 17.小鼠T/t复合体中的基因图谱。III:t致死基因在17号染色体上排列成三个簇。
Cell. 1984 Dec;39(3 Pt 2):565-72. doi: 10.1016/0092-8674(84)90463-x.
9
The cis-trans test shows no evidence for a functional relationship between two mouse t complex lethal mutations: implications for the evolution of t haplotypes.顺反测验未显示出两个小鼠t复合体致死突变之间存在功能关系的证据:对t单倍型进化的启示。
Genetics. 1986 Dec;114(4):1225-37. doi: 10.1093/genetics/114.4.1225.
10
[Characterization of a novel wild-type t(wMPI) haplotype of the house mouse (Mus domesticus L.) from Peru].[来自秘鲁的家鼠(小家鼠L.)新型野生型t(wMPI)单倍型的特征分析]
Genetika. 1999 Apr;35(4):556-8.