Del Sole Angelo, Lecchi Michela, Lucignani Giovanni
Department of Health Sciences, Centre of Molecular and Cellular Imaging (IMAGO), University of Milan, Milan, Italy Nuclear Medicine Unit, Department of Diagnostic Imaging, San Paolo Hospital, Milan, Italy
Department of Health Sciences, University of Milan and Nuclear Medicine Unit, San Paolo Hospital, Milan, Italy.
Radiat Prot Dosimetry. 2016 Mar;168(3):337-42. doi: 10.1093/rpd/ncv345. Epub 2015 May 20.
Given the large number of [(18)F]fluorodeoxyglucose (FDG) PET examinations performed annually throughout the world, reduction of the administered activity without compromise of the clinical information being sought is encouraged. Guidelines issued by the SNMMI and European Association of Nuclear Medicine (EANM) differ greatly on the choice of the activity that should be administered to patients: the EANM suggests a personalised activity based on the patient's body weight, whereas the SNMMI recommends the administration of fixed activities. The authors analysed a database of 24 716 [(18)F]FDG administrations performed worldwide in 15 PET centres to assess the degree of heterogeneity, in relation to available technology, operational protocols and reference guidelines. Median activities based on the patients' body weight were 43 % lower than fixed-activity administrations (p < 0.001). When TOF scanners are available, the median activity is lowered, but when comparing centres with the same technology or those that use the same operational protocols, weight-based activities are still significantly lower than fixed activities.
鉴于全球每年进行大量的[（18）F]氟脱氧葡萄糖（FDG）PET检查，因此鼓励在不影响所寻求临床信息的前提下减少给药剂量。美国核医学与分子影像学会（SNMMI）和欧洲核医学协会（EANM）发布的指南在应给予患者的给药剂量选择上存在很大差异：EANM建议根据患者体重进行个性化给药，而SNMMI则推荐给予固定剂量。作者分析了全球15个PET中心进行的24716次[（18）F]FDG给药的数据库，以评估与现有技术、操作方案和参考指南相关的异质性程度。基于患者体重的给药剂量中位数比固定剂量给药低43%（p<0.001）。当有时间飞跃（TOF）扫描仪可用时，给药剂量中位数会降低，但在比较采用相同技术或相同操作方案的中心时，基于体重的给药剂量仍显著低于固定剂量。
