Zhu Liangfu, Shao Qiuji, Li Tianxiao, Saver Jeffrey L, Li Li, Li Dujuan, Zhao Wenli, Jiang Weijian
Cerebrovascular Center, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, China.
The UCLA Stroke Center, University of California, Los Angeles, California, USA.
J Neurointerv Surg. 2016 May;8(5):526-30. doi: 10.1136/neurintsurg-2015-011721. Epub 2015 May 20.
To evaluate the recanalization efficacy and safety of a novel stent retriever in a swine model of acute arterial occlusion.
The JRecan thrombectomy device, a stent retriever with a weaving stent design, was evaluated in 18 occluded cervicocerebral vessels of swine. The flow restoration effect immediately upon deployment, the reperfusion rate after retrieval, thromboembolic events, and complications were assessed. The histologic structure of the renal arteries after retriever passage was measured to further assess the safety of JRecan.
Immediate flow restoration was achieved in 66.7% of occlusions (12/18). The reperfusion rate was 94.4% (two Thrombolysis in Cerebral Infarction (TICI) 2b and 15 TICI 3). Distal thromboembolic events did not occur. Microscopic examination of the arteries after retrieval showed mild degrees of endothelial loss in 96.6% (29/30), fibrin or platelet deposition in 53.3% (16/30), and disruption of the internal elastic lamina in 10% (3/30), without severe pathologic lesions.
The JRecan is highly effective at clot removal with a favorable safety profile and merits further development as a stent retriever for the treatment of acute ischemic stroke.
在猪急性动脉闭塞模型中评估一种新型支架取栓器的再通疗效和安全性。
在猪的18条闭塞性颈脑血管中评估JRecan血栓切除术装置，这是一种具有编织支架设计的支架取栓器。评估了部署后立即的血流恢复效果、取栓后的再灌注率、血栓栓塞事件和并发症。测量取栓器通过后肾动脉的组织结构，以进一步评估JRecan的安全性。
66.7%（12/18）的闭塞实现了立即血流恢复。再灌注率为94.4%（2例脑梗死溶栓（TICI）2b级和15例TICI 3级）。未发生远端血栓栓塞事件。取栓后动脉的显微镜检查显示，96.6%（29/30）有轻度内皮损失，53.3%（16/30）有纤维蛋白或血小板沉积，10%（3/30）有内弹性膜破坏，无严重病理病变。
JRecan在清除血栓方面非常有效，安全性良好，作为治疗急性缺血性卒中的支架取栓器值得进一步开发。
