Kobayashi Junji, Mabuchi Hiroshi
General Internal Medicine, Kanazawa Medical University, Uchinada, Daigaku, Ishikawa, Japan
Lipid Research Course, Kanazawa University Graduate School of Pharmaceutical, Health Sciences, Kakuma-machi, Kanazawa, Ishikawa, Japan.
Ann Clin Biochem. 2015 Nov;52(Pt 6):632-7. doi: 10.1177/0004563215590451. Epub 2015 May 20.
Lipoprotein lipase has long been known to hydrolyse triglycerides from triglycerides-rich lipoproteins. More recently, it has been shown to promote the binding of lipoproteins to various lipoprotein receptors. Evidence is also presented regarding the possible atherogenic role of lipoprotein lipase. In theory, lipoprotein lipase deficiency should help to clarify this question. However, the rarity of this condition means that it has not been possible to conduct epidemiological studies. An alternative approach is to investigate the correlation of lipoprotein lipase with onset of cardiovascular disease in prospective studies in large population-based cohorts. Complementary with this approach, animal models have been used to explore the atherogenicity of lipoprotein lipase expressed by macrophages.
长期以来，人们都知道脂蛋白脂肪酶能水解富含甘油三酯的脂蛋白中的甘油三酯。最近，研究表明它还能促进脂蛋白与各种脂蛋白受体的结合。也有证据表明脂蛋白脂肪酶可能具有致动脉粥样硬化作用。理论上，脂蛋白脂肪酶缺乏症应有助于阐明这一问题。然而，这种病症非常罕见，这意味着无法开展流行病学研究。另一种方法是在基于大规模人群的队列前瞻性研究中，调查脂蛋白脂肪酶与心血管疾病发病之间的相关性。作为这种方法的补充，动物模型已被用于探索巨噬细胞表达的脂蛋白脂肪酶的致动脉粥样硬化性。
