Uzarski Diane, Burke James, Turner Barbara, Vroom James, Short Nancy
Duke Translational Research Institute, Duke University, Durham, North Carolina, USA.
Duke Medicine, Duke University, Durham, North Carolina, USA.
Clin Transl Sci. 2015 Oct;8(5):553-7. doi: 10.1111/cts.12287. Epub 2015 May 21.
Researcher-initiated biobanks based at academic institutions contribute valuable biomarker and translational research advances to medicine. With many legacy banks once supported by federal funding, reductions in fiscal support threaten the future of existing and new biobanks. When the Brain Bank at Duke University's Bryan Alzheimer's Disease Center (ADRC) faced a funding crisis, a collaborative, multidisciplinary team embarked on a 2-year biobank sustainability project utilizing a comprehensive business strategy, dedicated project management, and a systems approach involving many Duke University entities. By synthesizing and applying existing knowledge, Duke Translational Medicine Institute created and launched a business model that can be adjusted and applied to legacy and start-up academic biobanks. This model provides a path to identify new funding mechanisms, while also emphasizing improved communication, business development, and a focus on collaborating with industry to improve access to biospecimens. Benchmarks for short-term Brain Bank stabilization have been successfully attained, and the evaluation of long-term sustainability metrics is ongoing.
基于学术机构的研究人员发起的生物样本库为医学贡献了有价值的生物标志物和转化研究进展。许多曾经由联邦资金支持的传统生物样本库，财政支持的减少威胁着现有和新生物样本库的未来。当杜克大学布莱恩阿尔茨海默病中心（ADRC）的脑库面临资金危机时，一个跨学科的合作团队启动了一个为期两年的生物样本库可持续性项目，采用了全面的商业战略、专门的项目管理以及涉及杜克大学多个实体的系统方法。通过综合和应用现有知识，杜克转化医学研究所创建并推出了一种商业模式，该模式可以进行调整并应用于传统和初创的学术生物样本库。这种模式提供了一条识别新资金机制的途径，同时还强调改善沟通、业务发展以及专注于与行业合作以改善生物样本的获取。短期脑库稳定的基准已成功实现，对长期可持续性指标的评估正在进行中。
