Kshettry Varun R, Hsieh Jason K, Ostrom Quinn T, Kruchko Carol, Benzel Edward C, Barnholtz-Sloan Jill S
*Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland, OH; †Cleveland Clinic Lerner College of Medicine, Cleveland, OH; ‡Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH; and §Central Brain Tumor Registry of the United States, Hinsdale, IL.
Spine (Phila Pa 1976). 2015 Aug 1;40(15):E886-9. doi: 10.1097/BRS.0000000000000974.
Cross-sectional study of US cancer registry data.
To present the current population-based descriptive epidemiology of spinal meningiomas in the United States.
Meningioma is the most common primary spinal tumor, yet there is a paucity of population-based data evaluating incidence according to age, sex, race, and ethnicity. Such data are necessary to assess the burden of spinal meningiomas on varying populations and to inform health care planning and future research.
The Central Brain Tumor Registry of the United States, which contains the largest aggregation of population-based data on the incidence of primary central nervous system tumors in the United States, was used. Age-adjusted incidence rates of spinal meningiomas from 2004 to 2010 were calculated by age at diagnosis, sex, race, and ethnicity. Annual percent change was calculated using Joinpoint to characterize temporal trends.
From 2004 to 2010, there were 7148 newly diagnosed spinal meningiomas, resulting in an overall age-adjusted incidence of 0.33 per 100,000 population. There was a nonsignificant increase in incidence over time (annual percent change: 0.8%, 95% confidence interval: -1.4 to 3.0). The highest incidence occurred in the 75- to 84-year old age group. Females had a much higher incidence than males (incidence rate ratio: 3.37; P < 0.0001). Asian Pacific Islanders and Caucasians had the highest incidence. Compared with Caucasians, African Americans and American Indian/Alaskan Native individuals had a significantly lower incidence (incidence rate ratio: 0.72, P < 0.0001; 0.52, P = 0.0003, respectively). Non-Hispanics had a significantly lower incidence than Hispanics (incidence rate ratio: 0.81, P < 0.0001).
Approximately 1000 spinal meningiomas were diagnosed in the United States per year, and the incidence was relatively stable. Advanced age, female sex, Asian Pacific Islander and Caucasian race, and Hispanic ethnicity were all associated with an increased incidence of spinal meningioma. This study represents the most comprehensive evaluation of population-based descriptive epidemiology of spinal meningiomas in the United States to date.
对美国癌症登记数据的横断面研究。
呈现美国当前基于人群的脊髓脑膜瘤描述性流行病学情况。
脑膜瘤是最常见的原发性脊髓肿瘤，但缺乏根据年龄、性别、种族和族裔评估发病率的基于人群的数据。此类数据对于评估脊髓脑膜瘤在不同人群中的负担以及为医疗保健规划和未来研究提供信息是必要的。
使用美国中枢脑肿瘤登记处，其包含美国基于人群的原发性中枢神经系统肿瘤发病率的最大汇总数据。按诊断时年龄、性别、种族和族裔计算2004年至2010年脊髓脑膜瘤的年龄调整发病率。使用Joinpoint计算年度百分比变化以描述时间趋势。
2004年至2010年，新诊断出7148例脊髓脑膜瘤，总体年龄调整发病率为每10万人0.33例。发病率随时间有不显著增加（年度百分比变化：0.8%，95%置信区间：-1.4至3.0）。最高发病率出现在75至84岁年龄组。女性发病率远高于男性（发病率比：3.37；P < 0.0001）。亚太岛民和白种人的发病率最高。与白种人相比，非裔美国人和美国印第安人/阿拉斯加原住民的发病率显著较低（发病率比：0.72，P < 0.0001；0.52，P = 0.0003）。非西班牙裔的发病率显著低于西班牙裔（发病率比：0.81，P < 0.0001）。
美国每年约诊断出1000例脊髓脑膜瘤，发病率相对稳定。高龄、女性、亚太岛民和白种人种族以及西班牙裔族裔均与脊髓脑膜瘤发病率增加相关。本研究是迄今为止对美国脊髓脑膜瘤基于人群的描述性流行病学最全面的评估。
2级。
