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Radiat Prot Dosimetry. 2015 Apr;164(3):376-82. doi: 10.1093/rpd/ncu292. Epub 2014 Sep 28.
2
American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part I: general principles.美国近距离放射治疗学会关于局部晚期宫颈癌的共识指南。第一部分：一般原则。
Brachytherapy. 2012 Jan-Feb;11(1):33-46. doi: 10.1016/j.brachy.2011.07.003.
3
A comparison of the biological effective dose of 50-kV electronic brachytherapy with (192)Ir high-dose-rate brachytherapy for vaginal cuff irradiation.50千伏电子近距离放射疗法与铱-192高剂量率近距离放射疗法用于阴道残端照射的生物等效剂量比较。
Brachytherapy. 2012 Sep-Oct;11(5):402-7. doi: 10.1016/j.brachy.2011.08.004. Epub 2011 Oct 12.
4
High-dose-rate interstitial brachytherapy with computed tomography-based treatment planning for patients with locally advanced uterine cervical carcinoma.高剂量率近距离间质放疗联合基于 CT 的治疗计划用于局部晚期宫颈癌患者。
J Radiat Res. 2011;52(4):490-5. doi: 10.1269/jrr.10189.
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High Dose Rate Brachytherapy in the Treatment of cervical cancer: preliminary experience with cobalt 60 Radionuclide source-A Prospective Study.高剂量率近距离放射治疗宫颈癌：钴 60 放射性核素源的初步经验——一项前瞻性研究。
Clin Med Insights Oncol. 2010 Aug 19;4:89-94. doi: 10.4137/cmo.s5269.
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A dosimetric comparison of Xoft Axxent Electronic Brachytherapy and iridium-192 high-dose-rate brachytherapy in the treatment of endometrial cancer.Xoft Axxent电子近距离放射治疗与铱-192高剂量率近距离放射治疗在子宫内膜癌治疗中的剂量学比较。
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Comparison of 60cobalt and 192iridium sources in high dose rate afterloading brachytherapy.高剂量率后装近距离放疗中60钴源与192铱源的比较
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8
Technical note: Dosimetric study of a new Co-60 source used in brachytherapy.技术说明：用于近距离放射治疗的新型钴-60源的剂量学研究。
Med Phys. 2007 Sep;34(9):3485-8. doi: 10.1118/1.2759602.
9
Dose-volume characteristics of a 50-kV electronic brachytherapy source for intracavitary accelerated partial breast irradiation.用于腔内加速部分乳腺照射的50千伏电子近距离治疗源的剂量体积特性
Brachytherapy. 2007 Jul-Sep;6(3):207-11. doi: 10.1016/j.brachy.2007.03.002.
10
A dosimetric comparison of MammoSite high-dose-rate brachytherapy and Xoft Axxent electronic brachytherapy.MammoSite高剂量率近距离放射治疗与Xoft Axxent电子近距离放射治疗的剂量学比较。
Brachytherapy. 2007 Apr-Jun;6(2):164-8. doi: 10.1016/j.brachy.2007.01.005.

用于宫颈癌图像引导近距离放射治疗治疗计划的Axxent-Xoft、铱-192（¹⁹²Ir）和钴-60（⁶⁰Co）高剂量率近距离放射治疗源的比较

Comparison of Axxent-Xoft, (192)Ir and (60)Co high-dose-rate brachytherapy sources for image-guided brachytherapy treatment planning for cervical cancer.

作者信息

Mobit P N, Packianathan S, He R, Yang C C

机构信息

1 Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS, USA.

2 Cameroon Oncology Center, PO Box 1870, Douala, Cameroon.

出版信息

Br J Radiol. 2015 Aug;88(1052):20150010. doi: 10.1259/bjr.20150010. Epub 2015 May 21.

DOI:10.1259/bjr.20150010
PMID:25996576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4651397/
Abstract

OBJECTIVE

To evaluate the dosimetric differences and similarities between treatment plans generated with Axxent-Xoft electronic brachytherapy source (Xoft-EBS), (192)Ir and (60)Co for tandem and ovoids (T&O) applicators.

METHODS

In this retrospective study, we replanned 10 patients previously treated with (192)Ir high-dose-rate brachytherapy. Prescription was 7 Gy × 4 fractions to Point A. For each original plan, we created two additional plans with Xoft-EBS and (60)Co. The dose to each organ at risk (OAR) was evaluated in terms of V(35%) and V(50%), the percentage volume receiving 35% and 50% of the prescription dose, respectively, and D(2cc), highest dose to a 2 cm(3) volume of an OAR.

RESULTS

There was no difference between plans generated by (192)Ir and (60)Co, but the plans generated using Xoft-EBS showed a reduction of up to 50% in V(35%), V(50%) and D(2cc). The volumes of the 200% and 150% isodose lines, however, were 74% and 34% greater than the comparable volumes generated with the (192)Ir source. Point B dose was on average only 16% of the Point A dose for plans generated with Xoft-EBS compared with 30% for plans generated with (192)Ir or (60)Co.

CONCLUSION

The Xoft-EBS can potentially replace either (192)Ir or (60)Co in T&O treatments. Xoft-EBS offers either better sparing of the OARs compared with (192)Ir or (60)Co or at least similar sparing. Xoft-EBS-generated plans had higher doses within the target volume than (192)Ir- or (60)Co-generated ones.

ADVANCES IN KNOWLEDGE

This work presents newer knowledge in dosimetric comparison between Xoft-EBS, (192)Ir or (60)Co sources for T&O implants.

摘要

目的

评估使用Axxent-Xoft电子近距离放射治疗源（Xoft-EBS）、铱-192（¹⁹²Ir）和钴-60（⁶⁰Co）为串形和卵圆形施源器（T&O）生成的治疗计划之间的剂量差异和相似性。

方法

在这项回顾性研究中，我们对10例先前接受过铱-192高剂量率近距离放射治疗的患者重新制定计划。处方剂量为A点7 Gy×4次分割。对于每个原始计划，我们使用Xoft-EBS和钴-60创建了另外两个计划。根据V(35%)和V(50%)评估每个危及器官（OAR）的剂量，V(35%)和V(50%)分别是接受35%和50%处方剂量的体积百分比，以及D(2cc)，即OAR中2 cm³体积所接受的最高剂量。

结果

铱-192和钴-60生成的计划之间没有差异，但使用Xoft-EBS生成的计划在V(35%)、V(50%)和D(2cc)方面显示最多降低了50%。然而，200%和150%等剂量线的体积比使用铱-192源生成的可比体积分别大74%和34%。与铱-192或钴-60生成的计划相比，Xoft-EBS生成的计划中B点剂量平均仅为A点剂量的16%，而铱-192或钴-60生成的计划中这一比例为30%。

结论

在T&O治疗中，Xoft-EBS有可能替代铱-192或钴-60。与铱-192或钴-60相比，Xoft-EBS对OAR的保护效果更好，或者至少相似。Xoft-EBS生成的计划在靶区内的剂量比铱-192或钴-60生成的计划更高。

知识进展

这项工作展示了关于Xoft-EBS、铱-192或钴-60源用于T&O植入的剂量学比较的新知识。