Payakova Virginia, Yordanov Angel, Kostova-Lefterova Desislava, Mutkurov Nikolay, Iliev Ilko, Valkov Marin, Encheva Elitsa, Hitova-Topkarova Desislava
Scientific and Innovative Program Med for Health, Medical University Pleven, 1, Saint Kliment Ohridski Street, 5800 Pleven, Bulgaria.
Department of Radiotherapy, UMHAT "Dr. Georgi Stranski", 8A Georgi Kochev Blvd., 5809 Pleven, Bulgaria.
J Clin Med. 2024 Dec 23;13(24):7849. doi: 10.3390/jcm13247849.
: The objective of this study is to prospectively collect dosimetric and clinical data on vaginal cuff electronic brachytherapy and propose a protocol for the procedure. Twenty-five patients who had proven endometrial or cervical carcinoma and had undergone radical hysterectomy have been treated with vaginal cuff electronic brachytherapy. Treatment session durations and doses to the targets and the organs at risk have been extracted from the treatment planning software. Patients have been followed up for early side effects for 3 months. Treatment session times ranged from 3.0 to 6.6 min. Mean coverage of the planned treatment volume with 100% of the prescribed dose was 90%, and with 95% of the prescribed dose was 95%. Doses in the bladder were lower than those achieved in previously published studies with a mean D2cc of 4.7 Gy, and doses in the rectum were higher with a mean D2cc of 5.3 Gy. The first-month adverse events included eight G1 and three G2 toxicities, while the events registered on the third month were two G2 vaginal dryness events and one G1 urinary tract obstruction, of which only one patient with vaginal dryness did not respond to local treatment. No local relapses have been detected. : Vaginal cuff electronic brachytherapy has demonstrated safety and effectiveness.
本研究的目的是前瞻性收集阴道残端电子近距离放射治疗的剂量学和临床数据，并提出该治疗方法的方案。25例经证实患有子宫内膜癌或宫颈癌且已接受根治性子宫切除术的患者接受了阴道残端电子近距离放射治疗。治疗疗程时长以及靶区和危及器官的剂量已从治疗计划软件中提取。对患者进行了3个月的早期副作用随访。治疗疗程时间为3.0至6.6分钟。计划治疗体积接受100%处方剂量的平均覆盖率为90%，接受95%处方剂量的平均覆盖率为95%。膀胱中的剂量低于先前发表的研究中的剂量，平均D2cc为4.7 Gy，直肠中的剂量较高，平均D2cc为5.3 Gy。第一个月的不良事件包括8例1级和3例2级毒性反应，而第三个月记录的事件为2例2级阴道干燥事件和1例1级尿路梗阻，其中只有1例阴道干燥患者对局部治疗无反应。未检测到局部复发。阴道残端电子近距离放射治疗已证明具有安全性和有效性。
