Drago Francesco, Ciccarese Giulia, Broccolo Francesco, Cozzani Emanuele, Parodi Aurora
Department of Dermatology, DISSAL, IRCCS A.O.U. San Martino-IST, Genoa, Italy.
Dermatology. 2015;231(1):9-14. doi: 10.1159/000381285. Epub 2015 May 12.
Pityriasis rosea (PR) is a common, self-limiting exanthematous disease associated with a systemic reactivation of human herpesvirus 6 (HHV-6) and/or HHV-7. It usually occurs in the second or third decade of life whereas it is uncommon in patients younger than 10 years. We studied the clinical features and virological parameters of 31 children with PR, comparing them with those in adults. Our findings indicate that PR presents different characteristics between children and adults, mainly consisting of time lapse between herald patch and generalized eruption, duration of the exanthem, oropharyngeal involvement and persistence of HHV-6 and HHV-7 plasma viremia. Overall, these results suggest that, following HHV-6 and/or HHV-7 systemic active infection, the pathogenetic mechanisms involved in PR may at least partly be different in children and adults.
玫瑰糠疹（PR）是一种常见的、自限性的发疹性疾病，与人类疱疹病毒6型（HHV-6）和/或HHV-7的全身再激活有关。它通常发生在人生的第二个或第三个十年，而在10岁以下的患者中并不常见。我们研究了31例玫瑰糠疹患儿的临床特征和病毒学参数，并将其与成人进行比较。我们的研究结果表明，玫瑰糠疹在儿童和成人中表现出不同的特征，主要包括先驱斑与泛发性皮疹之间的时间间隔、皮疹持续时间、口咽部受累情况以及HHV-6和HHV-7血浆病毒血症的持续时间。总体而言，这些结果表明，在HHV-6和/或HHV-7全身活动性感染后，玫瑰糠疹的发病机制在儿童和成人中可能至少部分不同。
