用于构建结构明确的氟糖蛋白的氟糖试剂的合成。
Synthesis of fluorosugar reagents for the construction of well-defined fluoroglycoproteins.
作者信息
Salvadó Míriam, Amgarten Beatrice, Castillón Sergio, Bernardes Gonçalo J L, Boutureira Omar
机构信息
†Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, C/Marcel·lí Domingo s/n, 43007 Tarragona, Spain.
‡Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, U.K.
出版信息
Org Lett. 2015 Jun 5;17(11):2836-9. doi: 10.1021/acs.orglett.5b01259. Epub 2015 May 22.
2-Deoxy-2-fluoroglycosyl iodides are privileged glycosyl donors for the stereoselective preparation of 1-Nu-β-fluorosugars, which are useful reagents for chemical site-selective protein glycosylation. Ready access to such β-fluorosugars enables the mild and efficient construction of well-defined fluoroglycoproteins.
2-脱氧-2-氟糖基碘化物是用于立体选择性制备1-Nu-β-氟糖的特殊糖基供体，1-Nu-β-氟糖是用于化学位点选择性蛋白质糖基化的有用试剂。能够方便地获得此类β-氟糖使得能够温和且高效地构建结构明确的氟糖蛋白。
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