Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, Missouri 63121, United States.
Department of Chemistry, Saint Louis University, 3501 Laclede Avenue, St. Louis, Missouri 63103, United States.
Chem Rev. 2022 Jul 13;122(13):11701-11758. doi: 10.1021/acs.chemrev.2c00029. Epub 2022 Jun 8.
Advances in synthetic carbohydrate chemistry have dramatically improved access to common glycans. However, many novel methods still fail to adequately address challenges associated with chemical glycosylation and glycan synthesis. Since a challenge of glycosylation has remained, scientists have been frequently returning to the traditional glycosyl donors. This review is dedicated to glycosyl halides that have played crucial roles in shaping the field of glycosciences and continue to pave the way toward our understanding of chemical glycosylation.
合成碳水化合物化学的进步极大地改善了常见糖的获取途径。然而，许多新方法仍然无法充分解决与化学糖基化和聚糖合成相关的挑战。由于糖基化的挑战仍然存在，科学家们经常回到传统的糖基供体。本综述专门介绍了卤代糖基，它们在塑造糖科学领域方面发挥了关键作用，并为我们对化学糖基化的理解铺平了道路。
