RiYang Lin, HangYing Yu, JunYan Qin, YaYu Li, YuHui Wang, YaZhen Yang, JiaZhen Yin, Jin Yu, Jun Ni, DongRong Yu
Nephrology Department, Hangzhou Hospital of TCM, Hangzhou, Zhejiang Province, China.
Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
J Ethnopharmacol. 2015 Aug 2;171:125-30. doi: 10.1016/j.jep.2015.05.008. Epub 2015 May 19.
Tongue coating diagnosis is a useful tool to examine the changes of a human body in Chinese Medicine. Tongue coating varies in thickness in kidney disease. However, little information exists regarding the association between clinical characters and tongue coating thickness in CKD patients.
This study was carried out to determine whether there is an association between tongue coating thickness and laboratory, histological variables in idiopathic membranous nephropathy patients: one group with thin tongue coating, the other with thick tongue coating.
During July 2012-March 2014, idiopathic membranous nephropathy patients(CKD 1-2 stage) with tongue coating thickness Score ≤7, or ≥11, were enrolled as thin tongue coating group or thick tongue coating group, from Hangzhou Hospital of TCM. Laboratory variables (Hemoglobin (Hb), albumin (Alb); eGFR; alanine transferase (ALT); aspartate aminotransferase (AST); triglyceride (TG); total cholesterone (TC); high density lipoprotein (HDL); low density lipoprotein (LDL); immunoglobin A, G, M; Complement 3, 4) and renal histological data (glomerular lesions; tubular-interstitial damage) were compared, between these two groups.
12 idiopathic MN patients (CKD 1-2 stage) with thin tongue coating (tongue coating thickness score ≤7) and 11 with thick tongue coating (tongue coating thickness score ≥11) were enrolled in our study. We found a significant lower level of TC and LDL, a significant lower level of AST, ALT in those thick tongue coating patients, compared with thin. No significant difference was observed in pathological lesion between thick and thin tongue coating patients.
Tongue coating thickness is associated with lipid metabolism in idiopathic MN patients (CKD 1-2 stages).
舌苔诊断是中医检查人体变化的一种有用工具。肾病患者的舌苔厚度会有所不同。然而，关于慢性肾脏病（CKD）患者临床特征与舌苔厚度之间的关联，目前所知甚少。
本研究旨在确定特发性膜性肾病患者的舌苔厚度与实验室指标、组织学变量之间是否存在关联：一组为薄舌苔，另一组为厚舌苔。
2012年7月至2014年3月期间，从杭州市中医院招募舌苔厚度评分≤7或≥11的特发性膜性肾病患者（CKD 1-2期），分别作为薄舌苔组或厚舌苔组。比较两组患者的实验室指标（血红蛋白（Hb）、白蛋白（Alb）、估算肾小球滤过率（eGFR）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、免疫球蛋白A、G、M、补体3、4）和肾脏组织学数据（肾小球病变、肾小管间质损伤）。
本研究纳入了12例薄舌苔（舌苔厚度评分≤7）的特发性膜性肾病患者（CKD 1-2期）和11例厚舌苔（舌苔厚度评分≥11）的患者。我们发现，厚舌苔患者的TC和LDL水平显著低于薄舌苔患者，AST、ALT水平也显著更低。厚舌苔和薄舌苔患者在病理病变方面未观察到显著差异。
特发性膜性肾病患者（CKD 1-2期）的舌苔厚度与脂质代谢有关。
