Koenig Michel
Laboratoire de Génétique de Maladies Rares, Institut Universitaire de Recherche Clinique, Université de Montpellier, 34000 Montpellier, France; Centre Hospitalier Universitaire de Montpellier, 34000 Montpellier, France.
J Theor Biol. 2015 Aug 21;379:94-7. doi: 10.1016/j.jtbi.2015.05.013. Epub 2015 May 18.
The gap between prebiotic chemistry and the RNA origin of life lies in the nature of the pre-ribonucleotides that initiated replication-like activity. The present paper illustrates how the constraints for self-catalytic synthesis of the building blocks point to ionic pairing of the first pre-ribonucleotides and point to a central role for nicotinate.
益生元化学与生命的RNA起源之间的差距在于引发类似复制活性的前核糖核苷酸的性质。本文阐述了构建模块的自催化合成所受的限制如何指向首批前核糖核苷酸的离子配对，并表明烟酸具有核心作用。
