早发性痴呆的神经心理学评估与鉴别诊断

Neuropsychological assessment and differential diagnosis in young-onset dementias.

作者信息

Sitek Emilia J, Barczak Anna, Harciarek Michał

机构信息

Neurology Department, St. Adalbert Hospital, Copernicus PL Sp. z o.o., Al. Jana Pawła II 50, Gdansk 80-462, Poland; Neurological and Psychiatric Nursing Department, Medical University of Gdansk, Al. Jana Pawła II 50, Gdansk 80-462, Poland.

Neurodegenerative Department, Neurology Clinic, MSW Hospital, Wołoska 137, Warsaw 02-507, Poland.

出版信息

Psychiatr Clin North Am. 2015 Jun;38(2):265-79. doi: 10.1016/j.psc.2015.01.003. Epub 2015 Mar 7.

DOI:10.1016/j.psc.2015.01.003

PMID:25998115

Abstract

Although Alzheimer's disease is the most common cause of dementia in the elderly, there are several conditions (ie, frontotemporal dementia or Huntington's disease) associated with a relatively earlier onset. This article provides arguments in favor of a comprehensive neuropsychological assessment in the differential diagnosis of young-onset dementia, as episodic memory impairment is not observed early in the course of most types of young-onset dementia that predominantly affect the domains of behavior, executive, language, and/or motor function.

摘要

尽管阿尔茨海默病是老年人痴呆最常见的病因，但有几种疾病（如额颞叶痴呆或亨廷顿病）发病相对较早。本文支持在早发性痴呆的鉴别诊断中进行全面的神经心理学评估，因为在大多数主要影响行为、执行、语言和/或运动功能领域的早发性痴呆病程早期并未观察到情景记忆损害。