Department of Primary and Community Care, Radboud University Medical Center, Nijmegen, the Netherlands.
Radboudumc Alzheimer Center, Nijmegen, the Netherlands.
J Alzheimers Dis. 2021;83(4):1891-1916. doi: 10.3233/JAD-210458.
There has been growing interest in young people living with dementia. Future research requires consensus on the terminology and operational definition of this group.
The purpose of this integrative review was to explore and include all operational definitions used to define dementia at a young age.
On August 14, 2020, the PubMed, Embase, Cinahl, and PsycInfo databases were searched for empirical and theoretical literature using Google. Various terms to describe and define 'dementia' and 'at a young age' were used to collect literature concerning terminology; age-related aspects, including cut-off ages and criteria; and etiologies of dementia at a young age.
The search yielded 6,891 empirical and 4,660 theoretical publications, resulting in the inclusion of 89 publications, including 36 publications containing an explicit discussion and 53 publications as confirmation. 'Young-onset dementia' was the most commonly used term of seven identified terms, in the last two decades. The age of 65 years at symptom onset was used most frequently when considering a total of six upper age limits and four criteria to define a cut-off age. Eight lower age limits and an option for subdivision based on age were included. We identified 251 different etiologies and 27 categories of etiologies.
Despite relative consensus on the term young-onset dementia and an age at symptom onset being used as a cut-off criterion, much is still unclear concerning possible etiologies of dementia at a young age. In the current study, controversies were detected for discussion in an international consensus study.
越来越多的人对患有痴呆症的年轻人感兴趣。未来的研究需要就这一群体的术语和操作定义达成共识。
本综述的目的是探索并包括用于定义年轻时痴呆的所有操作定义。
2020 年 8 月 14 日，使用 Google 在 PubMed、Embase、Cinahl 和 PsycInfo 数据库中搜索了描述性和理论文献。使用了各种术语来描述和定义“痴呆症”和“年轻时”，以收集有关术语、与年龄相关的方面（包括截止年龄和标准）以及年轻时痴呆症的病因的文献。
搜索结果产生了 6891 篇实证文献和 4660 篇理论文献，最终纳入了 89 篇文献，其中包括 36 篇明确讨论的文献和 53 篇确认文献。在过去的二十年中，“早发性痴呆症”是七个已确定术语中使用最广泛的术语。考虑到总共六个上限年龄和四个定义截止年龄的标准，发病时 65 岁的年龄使用最频繁。包括了 8 个下限年龄和基于年龄的细分选项。我们确定了 251 种不同的病因和 27 种病因类别。
尽管在术语“早发性痴呆症”和作为截止标准的发病年龄方面存在相对共识，但对于年轻时痴呆的可能病因仍存在许多不明之处。在当前研究中，争议点将在国际共识研究中进行讨论。
