循环肿瘤细胞的体外培养：一种指导癌症治疗的新兴资源。
Ex Vivo Culture of CTCs: An Emerging Resource to Guide Cancer Therapy.
作者信息
Maheswaran Shyamala, Haber Daniel A
机构信息
Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts. Howard Hughes Medical Institute, Chevy Chase, Maryland.
出版信息
Cancer Res. 2015 Jun 15;75(12):2411-5. doi: 10.1158/0008-5472.CAN-15-0145. Epub 2015 May 21.
Abstract
With increasing application of targeted therapies and the development of acquired resistance, much attention is being focused on developing in vitro and in vivo patient-specific tumor models for individualized therapeutic evaluation of cancers. Circulating tumor cells provide a source of noninvasively and sequentially sampled invasive cancer cells suitable for propagation in vitro. We review the advantages and challenges associated with ex vivo culture of tumor cells circulating in the blood of patients with cancer.
摘要
随着靶向治疗的应用日益广泛以及获得性耐药的出现，开发用于癌症个体化治疗评估的体外和体内患者特异性肿瘤模型受到了广泛关注。循环肿瘤细胞提供了一种可通过非侵入性和连续采样获得的侵袭性癌细胞来源，适合在体外进行培养。我们综述了与癌症患者血液中循环肿瘤细胞的体外培养相关的优势和挑战。
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