Messerotti Benvenuti Simone, Buodo Giulia, Mennella Rocco, Palomba Daniela
Department of General Psychology, University of Padova Padova, Italy.
Department of General Psychology, University of Padova Padova, Italy ; Center for Cognitive Neuroscience, University of Padova Padova, Italy.
Front Psychol. 2015 May 7;6:599. doi: 10.3389/fpsyg.2015.00599. eCollection 2015.
Somatic, but not cognitive-affective, symptoms of depression have been associated with reduced heart rate variability (HRV), and with poor prognosis in cardiovascular patients. However, factors concomitant with cardiovascular diseases may confound the relationship between somatic symptoms of depression and reduced HRV. Therefore, this study examined whether reduced HRV was differentially associated with cognitive-affective and somatic symptoms of depression in medically healthy individuals with and without dysphoria.
Self-reported cognitive-affective and somatic symptoms as measured with the Beck Depression Inventory-II questionnaire and time and frequency domain parameters of HRV were collected in 62 medically healthy individuals, of whom 25 with and 37 without dysphoria.
Somatic, but not cognitive-affective, symptoms of depression were inversely associated with SD of NN intervals (β = -0.476, p < 0.05), number of interval differences of successive NN intervals greater than 50 ms (NN50; β = -0.498, p < 0.03), and HRV total power (β = -0.494, p < 0.04) in the group with dysphoria, after controlling for sex, anxiety, and lifestyle factors. Cognitive-affective and somatic symptoms were not related to any of the HRV parameters in the group without dysphoria (all ps > 0.24).
By showing that the relationship between somatic depressive symptoms and reduced HRV extends to medically healthy individuals with dysphoria, the present findings suggest that this association is independent of factors concomitant with cardiovascular diseases. The present study also suggests that individuals with somatic rather than cognitive-affective subsets of depressive symptoms may be at greater risk for developing cardiovascular diseases.
抑郁症的躯体症状而非认知情感症状与心率变异性（HRV）降低以及心血管疾病患者的不良预后相关。然而，心血管疾病伴随的因素可能会混淆抑郁症躯体症状与HRV降低之间的关系。因此，本研究调查了在有或没有烦躁不安的医学健康个体中，HRV降低是否与抑郁症的认知情感症状和躯体症状存在差异关联。
采用贝克抑郁量表-II问卷测量的自我报告认知情感和躯体症状以及HRV的时域和频域参数，收集了62名医学健康个体的数据，其中25名有烦躁不安，37名没有烦躁不安。
在控制了性别、焦虑和生活方式因素后，抑郁症的躯体症状而非认知情感症状与烦躁不安组的NN间期标准差（β = -0.476，p < 0.05）、连续NN间期差值大于50毫秒的数量（NN50；β = -0.498，p < 0.03）以及HRV总功率（β = -0.494，p < 0.04）呈负相关。在没有烦躁不安组中，认知情感和躯体症状与任何HRV参数均无关联（所有p值> 0.24）。
本研究结果表明，躯体抑郁症状与HRV降低之间的关系延伸至有烦躁不安的医学健康个体，提示这种关联独立于心血管疾病伴随的因素。本研究还表明，具有躯体而非认知情感性抑郁症状子集的个体可能患心血管疾病的风险更高。
