心脏直视手术期间及术后头孢呋辛和庆大霉素的清除情况。
Elimination of cefuroxime and gentamicin during and after open heart surgery.
作者信息
Lippert S, Josephsen S D, Jendresen M, Sørensen T S, Gutschik E
机构信息
Department of Cardiothoracic Surgery, Rigshospitalet, Copenhagen, Denmark.
出版信息
J Antimicrob Chemother. 1989 Nov;24(5):775-80. doi: 10.1093/jac/24.5.775.
In eight consecutive adult heart surgery patients, serum concentrations of cefuroxime and gentamicin were studied during and after operation. Repeated doses of cefuroxime 1.5 g and gentamicin 80 mg were given. Intra-operative concentrations were deemed adequate (cefuroxime Cmin: 16-45 mg/l, gentamicin Cmin: 1.6-2.8 mg/l), and no differences (P = 0.05) could be demonstrated between elimination rates during and after open heart operation (cefuroxime T1/2 101 vs 111 min, gentamicin T1/2 191 vs 193 min).
在连续8例成人心脏手术患者中，研究了手术期间及术后头孢呋辛和庆大霉素的血清浓度。给予重复剂量的头孢呋辛1.5 g和庆大霉素80 mg。术中浓度被认为是足够的（头孢呋辛Cmin：16 - 45 mg/l，庆大霉素Cmin：1.6 - 2.8 mg/l），并且在心脏直视手术期间和术后的消除率之间未发现差异（P = 0.05）（头孢呋辛T1/2 101对111分钟，庆大霉素T1/2 191对193分钟）。
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