心脏直视手术期间及术后头孢呋辛和庆大霉素的清除情况。

Elimination of cefuroxime and gentamicin during and after open heart surgery.

作者信息

Lippert S, Josephsen S D, Jendresen M, Sørensen T S, Gutschik E

机构信息

Department of Cardiothoracic Surgery, Rigshospitalet, Copenhagen, Denmark.

出版信息

J Antimicrob Chemother. 1989 Nov;24(5):775-80. doi: 10.1093/jac/24.5.775.

DOI:10.1093/jac/24.5.775

PMID:2599997

Abstract

In eight consecutive adult heart surgery patients, serum concentrations of cefuroxime and gentamicin were studied during and after operation. Repeated doses of cefuroxime 1.5 g and gentamicin 80 mg were given. Intra-operative concentrations were deemed adequate (cefuroxime Cmin: 16-45 mg/l, gentamicin Cmin: 1.6-2.8 mg/l), and no differences (P = 0.05) could be demonstrated between elimination rates during and after open heart operation (cefuroxime T1/2 101 vs 111 min, gentamicin T1/2 191 vs 193 min).

摘要

在连续8例成人心脏手术患者中，研究了手术期间及术后头孢呋辛和庆大霉素的血清浓度。给予重复剂量的头孢呋辛1.5 g和庆大霉素80 mg。术中浓度被认为是足够的（头孢呋辛Cmin：16 - 45 mg/l，庆大霉素Cmin：1.6 - 2.8 mg/l），并且在心脏直视手术期间和术后的消除率之间未发现差异（P = 0.05）（头孢呋辛T1/2 101对111分钟，庆大霉素T1/2 191对193分钟）。