预防性胃肠外应用头孢呋辛：剖腹手术伤口的皮下浓度

Prophylactic parenteral cefuroxime: subcutaneous concentrations in laparotomy wounds.

作者信息

Huizinga W K, Hirshberg A, Thomson S R, Elson K I, Salisbury R T, Brock-Utne J G

机构信息

Department of Surgery, King Edward VIII Hospital, Durban, South Africa.

出版信息

J Hosp Infect. 1989 May;13(4):395-8. doi: 10.1016/0195-6701(89)90059-5.

DOI:10.1016/0195-6701(89)90059-5

PMID:2567770

Abstract

Plasma and subcutaneous adipose tissue cefuroxime concentrations were measured in laparotomy wounds, by means of high-pressure liquid chromatography, in 12 patients undergoing elective abdominal operations. After intravenous administration of 1.5 g cefuroxime at induction of anaesthesia, the measured concentrations in serum and wound tissue during a 2 h period were above the MIC 90 of most micro-organisms derived from the alimentary tract. Tissue peak levels were reached within 15 min and the tissue half life was 1.5 h.

摘要

通过高压液相色谱法，对12例接受择期腹部手术的患者剖腹手术伤口中的血浆和皮下脂肪组织头孢呋辛浓度进行了测量。在麻醉诱导时静脉注射1.5g头孢呋辛后，在2小时内测得的血清和伤口组织浓度高于大多数源自消化道的微生物的MIC90。组织峰值水平在15分钟内达到，组织半衰期为1.5小时。