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靶向蛋白质进行蛋白酶体降解——拟南芥ABI1蛋白磷酸酶2C的新功能

Targeting proteins for proteasomal degradation-a new function of Arabidopsis ABI1 protein phosphatase 2C.

作者信息

Ludwików Agnieszka

机构信息

Department of Biotechnology, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University , Poznan, Poland.

出版信息

Front Plant Sci. 2015 May 5;6:310. doi: 10.3389/fpls.2015.00310. eCollection 2015.

DOI:10.3389/fpls.2015.00310
PMID:25999974
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4419600/
Abstract

The ubiquitin/26S proteasome system (UPS) has been implicated in the regulation of many physiological processes including hormone signaling. The plant hormone abscisic acid (ABA) employs the UPS to control its own synthesis and signaling and to regulate stress response and tolerance. Among the known effectors of ABA signaling, the ABI1 (abscisic acid-insensitive 1) protein phosphatase, which belongs to group A of the type 2C protein phosphatases, is recognized as a key component of the pathway. Molecular and genetic evidence implicates this protein phosphatase in numerous plant responses. This mini-review discusses recent progress in understanding the role of ABI1 in ABA signaling, with particular emphasis on recent data that link ABI1 to protein degradation via the UPS.

摘要

泛素/26S蛋白酶体系统（UPS）参与调控包括激素信号传导在内的许多生理过程。植物激素脱落酸（ABA）利用UPS来控制自身的合成与信号传导，并调节应激反应和耐受性。在已知的ABA信号传导效应因子中，属于2C型蛋白磷酸酶A组的ABI1（脱落酸不敏感1）蛋白磷酸酶被认为是该信号通路的关键组成部分。分子和遗传学证据表明这种蛋白磷酸酶参与了众多植物反应。本综述讨论了在理解ABI1在ABA信号传导中作用方面的最新进展，特别强调了将ABI1与通过UPS进行的蛋白质降解联系起来的最新数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a224/4419600/34ac5718b8e7/fpls-06-00310-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a224/4419600/34ac5718b8e7/fpls-06-00310-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a224/4419600/34ac5718b8e7/fpls-06-00310-g0001.jpg

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