Jagodzik Przemysław, Tajdel-Zielinska Małgorzata, Ciesla Agata, Marczak Małgorzata, Ludwikow Agnieszka
Department of Plant Physiology, Institute of Experimental Biology, Faculty of Biology, Adam Mickiewicz University in Poznań, Poznań, Poland.
Department of Biotechnology, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University in Poznań, Poznań, Poland.
Front Plant Sci. 2018 Oct 8;9:1387. doi: 10.3389/fpls.2018.01387. eCollection 2018.
Mitogen-activated protein kinase (MAPK) modules play key roles in the transduction of environmental and developmental signals through phosphorylation of downstream signaling targets, including other kinases, enzymes, cytoskeletal proteins or transcription factors, in all eukaryotic cells. A typical MAPK cascade consists of at least three sequentially acting serine/threonine kinases, a MAP kinase kinase kinase (MAPKKK), a MAP kinase kinase (MAPKK) and finally, the MAP kinase (MAPK) itself, with each phosphorylating, and hence activating, the next kinase in the cascade. Recent advances in our understanding of hormone signaling pathways have led to the discovery of new regulatory systems. In particular, this research has revealed the emerging role of crosstalk between the protein components of various signaling pathways and the involvement of this crosstalk in multiple cellular processes. Here we provide an overview of current models and mechanisms of hormone signaling with a special emphasis on the role of MAPKs in cell signaling networks. In this review we highlight the mechanisms of crosstalk between MAPK cascades and plant hormone signaling pathways and summarize recent findings on MAPK regulation and function in various cellular processes.
丝裂原活化蛋白激酶（MAPK）模块在所有真核细胞中通过磷酸化下游信号靶点（包括其他激酶、酶、细胞骨架蛋白或转录因子）来传导环境信号和发育信号，发挥着关键作用。典型的MAPK级联反应至少由三种依次作用的丝氨酸/苏氨酸激酶组成，即MAP激酶激酶激酶（MAPKKK）、MAP激酶激酶（MAPKK），最后是MAP激酶（MAPK）本身，其中每一种激酶都会磷酸化并激活级联反应中的下一种激酶。我们对激素信号通路认识的最新进展促成了新调控系统的发现。特别是，这项研究揭示了各种信号通路的蛋白质成分之间相互作用的新作用，以及这种相互作用在多个细胞过程中的参与情况。在此，我们概述激素信号传导的当前模型和机制，并特别强调MAPK在细胞信号网络中的作用。在本综述中，我们着重介绍MAPK级联反应与植物激素信号通路之间相互作用的机制，并总结MAPK在各种细胞过程中的调控和功能的最新研究成果。
